eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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1/2009
vol. 34
 
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abstract:

Clinical immunology
Age-dependence of angiogenic activity of human serum

Piotr Skopiński
,
Ewa Skopińska-Różewska
,
Leszek Jung
,
Ewa Sommer
,
Joanna Chorostowska-Wynimko
,
Aleksander Wasiutyński

Centr Eur J Immunol 2009; 34 (1): 53-56
Online publish date: 2009/03/31
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Human serum contains various factors able to modulate neovascularisation in mouse cutaneous angiogenesis test (SIA, serum induced angiogenesis). Among them are two important growth factors: vascular endothelial growth factor (VEGF) and interleukin 18
(IL-18). In our previous study, each of them, in doses comparable to concentration in human serum, presented pro-angiogenic activity after intradermal introduction into mice skin.
The aim of the present study was to evaluate total in vivo angiogenic activity as well as concentration of VEGF and IL-18 in sera collected from 60 healthy people of various age (20-86 years old), and to analyze whether some correlations exist between studied parameters and persons age.
We have found negative correlation between age and in vivo activity of serum, negative correlation between age and VEGF concentration and positive correlation between age and IL-18 level.
keywords:

healthy people, age, sera, angiogenesis, VEGF, IL-18
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