eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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2/2010
vol. 35
 
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abstract:

Clinical immunology
Programmed lymphocytes death in pancreatic cancer patients

Sylwia Kędziora
,
Robert Słotwiński
,
Waldemar L. Olszewski
,
Maciej Słodkowski
,
Gustaw Lech
,
Marzanna Zaleska
,
Anna Włuka
,
Anna Domaszewska
,
Ireneusz W. Krasnodębski

Centr Eur J Immunol 2010; 35 (2): 84-89
Online publish date: 2010/05/10
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To evaluate the status of immune cell apoptosis we investigated expression of some proteins connected with programmed lymphocytes death of pancreatic cancer patients in comparison with healthy controls the expressions of Bcl-2, Bax, Cas3, Cas9, PARP-1 and TNFR1 proteins of peripheral blood lymphocytes were assessed by western blotting. Results of the study show a significantly lower expression of Bcl-2, Bax and PARP-1 and a significantly higher expression of caspase 3, 9 and TNFR1 in the lymphocytes of patients with pancreatic cancer as compared to the healthy control. In conclusion: our studies show a down-regulation of antiapoptotic signaling system in the lymphocytes of patients with pancreatic cancer and a switch to apoptosis. These alterations may lead to lymphocytes dysfunction and immune system suppression.
keywords:

pancreatic cancer, apoptosis, immune dysfunction
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