Experimental immunology<br>The effect of Echinacea purpurea on the morphology, angiogenic activity and vascular endothelial growth factor (VEGF) concentration of murine L-1 sarcoma tumors

Aleksander Wasiutyński; Barbara J. Bałan; Ewa Skopińska-Różewska; Andrzej K. Siwicki; Henryk Skurzak; Joanna Chorostowska-Wynimko; Ewa Sommer; Michał Mazurkiewicz

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ISSN: 1426-3912

Central European Journal of Immunology

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1/2009
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abstract:

Experimental immunology
The effect of Echinacea purpurea on the morphology, angiogenic activity and vascular endothelial growth factor (VEGF) concentration of murine L-1 sarcoma tumors

Aleksander Wasiutyński

,

Barbara J. Bałan

,

Ewa Skopińska-Różewska

,

Andrzej K. Siwicki

,

Henryk Skurzak

,

Joanna Chorostowska-Wynimko

,

Ewa Sommer

,

Michał Mazurkiewicz

Centr Eur J Immunol 2009; 34 (1): 38-41

Online publish date: 2009/03/31

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AMA

Wasiutyński A, Bałan B, Skopińska-Różewska E, et al. Experimental immunologyThe effect of Echinacea purpurea on the morphology, angiogenic activity and vascular endothelial growth factor (VEGF) concentration of murine L-1 sarcoma tumors. Central European Journal of Immunology. 2009;34(1):38-41.

APA

Wasiutyński, A., Bałan, B., Skopińska-Różewska, E., Siwicki, A., Skurzak, H.,  & Chorostowska-Wynimko, J. et al. (2009). Experimental immunologyThe effect of Echinacea purpurea on the morphology, angiogenic activity and vascular endothelial growth factor (VEGF) concentration of murine L-1 sarcoma tumors. Central European Journal of Immunology, 34(1), 38-41.

Chicago

Wasiutyński, Aleksander, Barbara J. Bałan, Ewa Skopińska-Różewska, Andrzej K. Siwicki, Henryk Skurzak, Joanna Chorostowska-Wynimko,  and Ewa Sommer et al. 2009. "Experimental immunologyThe effect of Echinacea purpurea on the morphology, angiogenic activity and vascular endothelial growth factor (VEGF) concentration of murine L-1 sarcoma tumors". Central European Journal of Immunology 34 (1): 38-41.

Harvard

Wasiutyński, A., Bałan, B., Skopińska-Różewska, E., Siwicki, A., Skurzak, H., Chorostowska-Wynimko, J., Sommer, E.,  and Mazurkiewicz, M. (2009). Experimental immunologyThe effect of Echinacea purpurea on the morphology, angiogenic activity and vascular endothelial growth factor (VEGF) concentration of murine L-1 sarcoma tumors. Central European Journal of Immunology, 34(1), pp.38-41.

MLA

Wasiutyński, Aleksander et al. "Experimental immunologyThe effect of Echinacea purpurea on the morphology, angiogenic activity and vascular endothelial growth factor (VEGF) concentration of murine L-1 sarcoma tumors." Central European Journal of Immunology, vol. 34, no. 1, 2009, pp. 38-41.

Vancouver

Wasiutyński A, Bałan B, Skopińska-Różewska E, Siwicki A, Skurzak H, Chorostowska-Wynimko J et al. Experimental immunologyThe effect of Echinacea purpurea on the morphology, angiogenic activity and vascular endothelial growth factor (VEGF) concentration of murine L-1 sarcoma tumors. Central European Journal of Immunology. 2009;34(1):38-41.

The aim of the present study was to evaluate the effect of feeding mice Echinacea purpurea-containing drugs on 1) neovascular response induced in mice by L-1 sarcoma cells 3 days after intracutaneous grafting 2) morphology, angiogenic activity and VEGF concentration of murine sarcoma L-1 tumors 7 days after intracutaneous cells transplantation.
Material and Methods: Echinacea purpurea-containing drugs: Immunal forte tablets (LEK, Slovenia) and Echinapur tablets (Herbapol Poznań), 0.6 mg per day. Animals: inbred Balb/c mice 8-10 weeks old. Tumor cells: murine L-1 sarcoma from Warsaw Cancer Center Collection. Methods: cutaneous angiogenesis assay according to Sidky and Auerbach, VEGF concentration measurement (ELISA) and histological evaluation of L-1 sarcoma tumors 7 days after transplantation of cells.
Results: Echinapur diminished angiogenesis induced by murine L-1 sarcoma cells 3 days after intradermal cells injection. Both Echinapur and Immunal reduced VEGF concentration in L1 sarcoma tumor tissue, evaluated 7 days after intradermal cells grafting. There were no differences in mass and diameter of tumors between investigated and control groups. In Echinacea-fed groups, however, there were less small blood vessels at a margin of tumor.

keywords:

Experimental immunologyThe effect of Echinacea purpurea on the morphology, angiogenic activity and vascular endothelial growth factor (VEGF) concentration of murine L-1 sarcoma tumors

Aleksander Wasiutyński , Barbara J. Bałan , Ewa Skopińska-Różewska , Andrzej K. Siwicki , Henryk Skurzak , Joanna Chorostowska-Wynimko , Ewa Sommer , Michał Mazurkiewicz

Echinacea purpurea, L-1 sarcoma, mice

Experimental immunology
The effect of Echinacea purpurea on the morphology, angiogenic activity and vascular endothelial growth factor (VEGF) concentration of murine L-1 sarcoma tumors

Aleksander Wasiutyński

,

Barbara J. Bałan

,

Ewa Skopińska-Różewska

,

Andrzej K. Siwicki

,

Henryk Skurzak

,

Joanna Chorostowska-Wynimko

,

Ewa Sommer

,

Michał Mazurkiewicz