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3/2024
vol. 41
abstract:
Original paper
Physical activity shifts gut microbiota structure in aged subjects
with overweight/obesity and metabolic syndrome
Patricia Ruiz-Limón
1, 2
,
Jananee Muralidharan
2, 3
,
Ana M. Gomez-Perez
1, 2
,
Jordi Salas-Salvadó
2, 3, 10
,
Laura Torres-Collado
4, 5
,
M. Rosa Bernal-López
12, 2
,
Isabel Moreno-Indias
1, 2
,
Francisco J. Tinahones
1, 2
1.
Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, The Biomedical Research
Institute of Malaga and Platform in Nanomedicine (IBIMA BIONAND Platform), University of Malaga,
29016 Malaga, Spain
2.
CIBER in Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Health Institute, 28029 Madrid,
Spain
3.
University of Rovira i Virgili, Department of Biochemistry and Biotechnology, Human Nutrition Unit, 43003 Reus,
Spain
4.
Institute of Health and Biomedical Research of Alicante. University of Miguel Hernández (ISABIAL-UMH),
03010 Alicante, Spain
5.
CIBER Epidemiology and Public Health (CIBERESP), Carlos III Health Institute, 28029 Madrid, Spain
6.
Department of Preventive Medicine, University of Valencia, 46100 Valencia, Spain
7.
Cardiovascular Risk and Nutrition (Regicor Study Group), Hospital del Mar Research Institute (IMIM),
08003 Barcelona, Spain
8.
Endocrinology and Nutrition Department, Clinic Universitary Hospital, 08036 Barcelona, Spain
9.
August Pi i Sunyer Biomedical Research Institute (IDIBAPS), 08036 Barcelona, Spain
10.
Pere i Virgili Health Research Institute (IISPV). San Joan University Hospital, 43003 Reus, Spain
11.
Department of Computer Sciences. University Jaume I, Castellon, Spain
12.
Department of Internal Medicine of Regional University Hospital, Institute of Biomedical Research in Malaga
(IBIMA), 29009 Málaga, Spain
Biol Sport. 2024; 41(3): 47–60
Online publish date: 2023/12/20
PlumX metrics:
We aimed to identify how physical activity (PA), within the context of a Mediterranean diet, affects metabolic variables and gut microbiota in older individuals with overweight/obesity and metabolic syndrome. Observational analysis was conducted as part of the PREDIMED Plus study with 152 males and 145 females with overweight/obesity and metabolic syndrome. General assessments, anthropometric and biochemical measurements, and gut microbial 16S rRNA sequencing data were analyzed at baseline and 1-year of follow-up. Participants were stratified by tertiles of 1-year change in total PA-related energy expenditure ranging from -98.77 to 1099.99 METs (min/week). The total PA percentage of change was reduced in tertile 1 (-44.83±24.94), increased in tertile 2 (28.96±23.33) and tertile 3 (273.64±221.42). Beta diversity analysis showed differences in the gut microbiota population within each tertile group. Significant differences were found at phylum, family, and genus levels in the gut microbiota of the three tertile groups at baseline and 1-year timepoint. Tertile 3, the group with the greatest increase in PA, was characterized by increases in their levels of Sutterella, Bilophila, and Lachnospira bacteria as well as a reduction in Collinsella. Moreover, this tertile showed a different pattern in its predicted metabolic capacities to the other groups. Our results have demonstrated that changes in PA such as lifestyle and Mediterranean diet induces specific variations in the gut microbiota profile. This modulation of gut microbiome populations and their metabolic capacities may contribute to the health of the aged individuals with overweight/obesity and metabolic syndrome.
keywords:
Gut microbiota, Metabolic syndrome, Obesity, Overweight, Physical activity
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