The level of myeloid-derived suppressor cells positively correlates with regulatory T cells in the blood of children with transient hypogammaglobulinaemia of infancy

Siemińska I, Rutkowska-Zapała M, Bukowska-Strakova K, et al. The level of myeloid-derived suppressor cells positively correlates with regulatory T cells in the blood of children with transient hypogammaglobulinaemia of infancy. Central European Journal of Immunology. 2018;43(4):413-420. doi:10.5114/ceji.2018.81359.

APA

Siemińska, I., Rutkowska-Zapała, M., Bukowska-Strakova, K., Gruca, A., Szaflarska, A.,  & Kobylarz, K. et al. (2018). The level of myeloid-derived suppressor cells positively correlates with regulatory T cells in the blood of children with transient hypogammaglobulinaemia of infancy. Central European Journal of Immunology, 43(4), 413-420. https://doi.org/10.5114/ceji.2018.81359

Chicago

Siemińska, Izabela, Magdalena Rutkowska-Zapała, Karolina Bukowska-Strakova, Anna Gruca, Anna Szaflarska, Krzysztof Kobylarz,  and Maciej Siedlar et al. 2018. "The level of myeloid-derived suppressor cells positively correlates with regulatory T cells in the blood of children with transient hypogammaglobulinaemia of infancy". Central European Journal of Immunology 43 (4): 413-420. doi:10.5114/ceji.2018.81359.

Harvard

Siemińska, I., Rutkowska-Zapała, M., Bukowska-Strakova, K., Gruca, A., Szaflarska, A., Kobylarz, K., Siedlar, M.,  and Baran, J. (2018). The level of myeloid-derived suppressor cells positively correlates with regulatory T cells in the blood of children with transient hypogammaglobulinaemia of infancy. Central European Journal of Immunology, 43(4), pp.413-420. https://doi.org/10.5114/ceji.2018.81359

MLA

Siemińska, Izabela et al. "The level of myeloid-derived suppressor cells positively correlates with regulatory T cells in the blood of children with transient hypogammaglobulinaemia of infancy." Central European Journal of Immunology, vol. 43, no. 4, 2018, pp. 413-420. doi:10.5114/ceji.2018.81359.

Vancouver

Siemińska I, Rutkowska-Zapała M, Bukowska-Strakova K, Gruca A, Szaflarska A, Kobylarz K et al. The level of myeloid-derived suppressor cells positively correlates with regulatory T cells in the blood of children with transient hypogammaglobulinaemia of infancy. Central European Journal of Immunology. 2018;43(4):413-420. doi:10.5114/ceji.2018.81359.

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Introduction
Transient hypogammaglobulinaemia of infancy (THI) is a primary immunodeficiency characterised by low levels of immunoglobulin G (often with concomitant decrease of IgA and sometimes also of IgM) with still unknown exact reason. A delayed normalisation of the immunoglobulin level in THI may be associated with a transiently elevated number of regulatory T cells (Treg). Although in cancer and chronic inflammation it was shown that the level of Treg cells can be increased by myeloid-derived suppressor cells (MDSCs), until now no studies have been performed in the context of the role of MDSCs in THI and their correlation with Treg cells. Consequently, we aimed to determine the occurrence of MDSCs in the peripheral blood of children with THI and correlate their level with the level of Treg cells.

Material and methods
Flow cytometry analyses of Mo-MDSCs and Gr-MDSCs, characterised as HLA-DR^–CD11b⁺CD15^–CD14⁺ and HLA-DR^–CD11b⁺CD15⁺CD14^–, respectively, and Treg (CD4+CD25+Foxp3+) cells were performed.

Results
The proportion of Mo-MDSCs and Gr-MDSCs was significantly higher in the group of THI patients with elevated level of Treg cells (from the 95% confidence interval level of healthy controls). The cells with Mo-MDSC and Gr-MDSC characteristics positively correlated with the level of Treg cells. Moreover, children with a higher proportion of circulating Treg cells, and thereby higher level of MDSCs, showed delayed normalisation of IgG level and recovery.

Conclusions
These findings show for the first time that MDSCs may be involved in the pathomechanism of THI, probably acting through the induction of Treg cells.

keywords:

The level of myeloid-derived suppressor cells positively correlates with regulatory T cells in the blood of children with transient hypogammaglobulinaemia of infancy

Izabela Siemińska , Magdalena Rutkowska-Zapała , Karolina Bukowska-Strakova , Anna Gruca , Anna Szaflarska , Krzysztof Kobylarz , Maciej Siedlar , Jarek Baran

MDSCs, regulatory T cells, THI

Izabela Siemińska

,

Magdalena Rutkowska-Zapała

,

Karolina Bukowska-Strakova

,

Anna Gruca

,

Anna Szaflarska

,

Krzysztof Kobylarz

,

Maciej Siedlar

,

Jarek Baran