-2518 A/G MCP-1 but not -403 G/A RANTES gene polymorphism is associated with enhanced risk of basal cell carcinoma

Iwona Chlebicka; Aleksandra Stefaniak; Łukasz Matusiak; Jacek Szepietowski

doi:10.5114/pdia.2015.55178

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Original paper

-2518 A/G MCP-1 but not -403 G/A RANTES gene polymorphism is associated with enhanced risk of basal cell carcinoma

Iwona Chlebicka

¹

,

Aleksandra Stefaniak

¹

,

Łukasz Matusiak

¹

,

Jacek C. Szepietowski

¹

Department of Dermatology, Venereology, and Allergology, Wroclaw Medical University, Wroclaw, Poland

Adv Dermatol Allergol 2021; XXXVIII (6): 1086-1091

DOI: https://doi.org/10.5114/pdia.2015.55178

Online publish date: 2022/01/07

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Introduction
Basal cell carcinoma (BCC) is the most common cancer in humans, but the reporting of patients with BCC is still not complete. There are a limited number of analyses in the literature on BCC epidemiology.

Aim
To study the epidemiological as well as clinical aspects of BCC by analysing a single centre’s experience in the Lower Silesia region of Poland.

Material and methods
We investigated 180 patients with BCC treated in the Unit of Dermatosurgery, Department of Dermatology, Venereology, and Allergology of Wroclaw Medical University between September 2017 and December 2019.

Results
The mean age of patients with BCC was 70.5 ±11.9 years. The most frequently diagnosed type of BCC was nodular type, at 72% of all patients. BCC occurred most commonly on the face and neck area, at 132 (73.3%), without a statistical difference between males and females. The vast majority of cancers were located on the nose. There was a personal history of skin cancer in 29% of our patients. In 127 (70.6%) subjects, the diameter of the BCC on the day of excision was less than 2 cm.

Conclusions
The clinical characteristics of our cohort of BCC patients has some similarities with that reported from central Poland and other European countries. However, we found an increase in the incidence of BCC among females.

keywords:

-2518 A/G MCP-1 but not -403 G/A RANTES gene polymorphism is associated with enhanced risk of basal cell carcinoma

Iwona Chlebicka 1 , Aleksandra Stefaniak 1 , Łukasz Matusiak 1 , Jacek C. Szepietowski 1

basal cell carcinoma, skin cancer, epidemiology

Iwona Chlebicka

¹

,

Aleksandra Stefaniak

¹

,

Łukasz Matusiak

¹

,

Jacek C. Szepietowski

¹