A radiobiological study of the schemes with a low number of fractions in high-dose-rate brachytherapy as monotherapy for prostate cancer

Damián Guirado; Samuel Ruiz-Arrebola; Ana Tornero-López; Jose de la Vega; Pedro J. Prada; Antonio Lallena

doi:10.5114/jcb.2020.94492

eISSN: 2081-2841
ISSN: 1689-832X

Journal of Contemporary Brachytherapy

Current Issue Archive Supplements Articles in Press Journal Information Aims and Scope Editorial Office Editorial Board Register as Author Register as Reviewer Instructions for Authors Abstracting and indexing Subscription Advertising Information Links

Editorial System

Submit your Manuscript

2/2020
vol. 12

Send email

Copy url:

abstract:

Original paper

A radiobiological study of the schemes with a low number of fractions in high-dose-rate brachytherapy as monotherapy for prostate cancer

Damián Guirado

^{1, 2, 3}

,

Samuel Ruiz-Arrebola

⁴

,

Ana M. Tornero-López

⁵

,

Jose M. de la Vega

^{1, 2}

,

Pedro J. Prada

⁴

,

Antonio M. Lallena

^{2, 6}

Unidad de Radiofísica, Hospital Universitario Clínico “San Cecilio”, E-18016 Granada, Spain
Instituto de Investigación Biosanitaria (ibs. GRANADA), Complejo Hospitalario Universitario de Granada/Universidad de Granada, Granada, Spain
CIBER de Epidemiología y Salud Pública (CIBERESP), Granada, Spain
Servicio de Oncología Radioterápica, Hospital Universitario “Marqués de Valdecilla”, Santander, Spain
Servicio de Radiofísica y Protección Radiológica, Hospital Universitario Dr. Negrín, Las Palmas de Gran Canaria, Spain
Departamento de Física Atómica, Molecular y Nuclear, Universidad de Granada, Granada, Spain

J Contemp Brachytherapy 2020; 12, 2: 193–200

DOI: https://doi.org/10.5114/jcb.2020.94492

Online publish date: 2020/04/18

View full text Get citation

EndNote

Papers, Reference Manager, RefWorks, Zotero

AMA

Guirado D, Ruiz-Arrebola S, Tornero-López AM, de la Vega JM, Prada P, Lallena AM. A radiobiological study of the schemes with a low number of fractions in high-dose-rate brachytherapy as monotherapy for prostate cancer. Journal of Contemporary Brachytherapy. 2020;12(2):193-200. doi:10.5114/jcb.2020.94492.

APA

Guirado, D., Ruiz-Arrebola, S., Tornero-López, A. M., de la Vega, J. M., Prada, P.,  & Lallena, A. M. (2020). A radiobiological study of the schemes with a low number of fractions in high-dose-rate brachytherapy as monotherapy for prostate cancer. Journal of Contemporary Brachytherapy, 12(2), 193-200. https://doi.org/10.5114/jcb.2020.94492

Chicago

Guirado, Damián, Samuel Ruiz-Arrebola, Ana M Tornero-López, Jose M de la Vega, Pedro J. Prada,  and Antonio M Lallena. 2020. "A radiobiological study of the schemes with a low number of fractions in high-dose-rate brachytherapy as monotherapy for prostate cancer". Journal of Contemporary Brachytherapy 12 (2): 193-200. doi:10.5114/jcb.2020.94492.

Harvard

Guirado, D., Ruiz-Arrebola, S., Tornero-López, A., de la Vega, J., Prada, P.,  and Lallena, A. (2020). A radiobiological study of the schemes with a low number of fractions in high-dose-rate brachytherapy as monotherapy for prostate cancer. Journal of Contemporary Brachytherapy, 12(2), pp.193-200. https://doi.org/10.5114/jcb.2020.94492

MLA

Guirado, Damián et al. "A radiobiological study of the schemes with a low number of fractions in high-dose-rate brachytherapy as monotherapy for prostate cancer." Journal of Contemporary Brachytherapy, vol. 12, no. 2, 2020, pp. 193-200. doi:10.5114/jcb.2020.94492.

Vancouver

Guirado D, Ruiz-Arrebola S, Tornero-López A, de la Vega J, Prada P, Lallena A. A radiobiological study of the schemes with a low number of fractions in high-dose-rate brachytherapy as monotherapy for prostate cancer. Journal of Contemporary Brachytherapy. 2020;12(2):193-200. doi:10.5114/jcb.2020.94492.

Purpose
Schemes with high doses per fraction and small number of fractions are commonly used in high-dose-rate brachytherapy (HDR-BT) for prostate cancer. Our aim was to analyze the differences between published clinical results and the predictions of radiobiological models for absorbed dose required in a single fraction monotherapy HDR-BT.

Material and methods
Published HDR-BT clinical results for low- and intermediate-risk patients with prostate cancer were revised. For 13 clinical studies with 16 fractionation schedules between 1 and 9 fractions, a dose-response relation in terms of the biochemical control probability (BC) was established using Monte Carlo-based statistical methods.

Results
We obtained a value of / = 22.8 Gy (15.1-60.2 Gy) (95% CI) much larger than the values in the range 1.5-3.0 Gy that are usually considered to compare the results of different fractionation schemes in prostate cancer radiotherapy using doses per fraction below 6 Gy. The doses in a single fraction producing BC = 90% and 95% were 22.3 Gy (21.5-24.2 Gy) and 24.3 Gy (23.0-27.9 Gy), respectively.

Conclusions
The / obtained in our analysis of 22.8 Gy for a range of dose per fraction between 6 and 20.5 Gy was much greater than the one currently estimated for prostate cancer using low doses per fraction. This high value of / explains reasonably well the data available in the region of high doses per fraction considered.

keywords:

A radiobiological study of the schemes with a low number of fractions in high-dose-rate brachytherapy as monotherapy for prostate cancer

Damián Guirado 1, 2, 3 , Samuel Ruiz-Arrebola 4 , Ana M. Tornero-López 5 , Jose M. de la Vega 1, 2 , Pedro J. Prada 4 , Antonio M. Lallena 2, 6

HDR brachytherapy, prostate cancer, monotherapy

Damián Guirado

^{1, 2, 3}

,

Samuel Ruiz-Arrebola

⁴

,

Ana M. Tornero-López

⁵

,

Jose M. de la Vega

^{1, 2}

,

Pedro J. Prada

⁴

,

Antonio M. Lallena

^{2, 6}