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ISSN: 1689-832X
Journal of Contemporary Brachytherapy
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5/2018
vol. 10
 
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abstract:
Review paper

A systematic review of treating recurrent head and neck cancer: a reintroduction of brachytherapy with or without surgery

Julianna Rodin
,
Voichita Bar-Ad
,
David Cognetti
,
Joseph Curry
,
Jennifer Johnson
,
Chad Zender
,
Laura Doyle
,
David Kutler
,
Benjamin Leiby
,
William Keane
,
Adam Luginbuhl

J Contemp Brachytherapy 2018; 10, 5: 454–462
DOI: https://doi.org/10.5114/jcb.2018.79399
Online publish date: 2018/10/31
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Purpose
To review brachytherapy use in recurrent head and neck carcinoma (RHNC) with focus on its efficacy and complication rates.

Material and methods
A literature search of PubMed, Ovid, Google Scholar, and Scopus was conducted from 1990 to 2017. Publications describing treatment of RHNC with brachytherapy with or without surgery were included. The focus of this review is on oncologic outcomes and the safety of brachytherapy in the recurrent setting.

Results
Thirty studies involving RHNC treatment with brachytherapy were reviewed. Brachytherapy as adjunctive treatment to surgical resection appears to be associated with an improved local regional control and overall survival, when compared with the published rates for re-irradiation utilizing external beam radiotherapy (RT) or brachytherapy alone. Safety data remains variable with different isotopes and dose rates with implantable brachytherapy demonstrating a tolerable side effect profile.

Conclusions
Although surgery remains a mainstay treatment for RHNC, intraoperative interstitial brachytherapy delivery as adjunctive therapy may improve the treatment outcome and may be associated with fewer complication rates as compared to reirradiation using external beam radiotherapy. Further investigations are required to elucidate the role of brachytherapy for RHNC.

keywords:

cesium, head and neck cancer, recurrent

  
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