Accelerated partial breast irradiation in a single 18 Gy fraction with high-dose-rate brachytherapy: preliminary results

Javier Anchuelo Latorre; Piedad Galdós; Lucía Alonso Buznego; Ana García Blanco; Juan Cardenal; María Ferri; Iván Díaz de Cerio; Elisabet Arrojo; Nicolás Sierrasesúmaga; Mónica González Noriega; Ana De Juan Ferré; Rosa Fabregat; Samuel Ruíz; Pedro J. Prada

doi:10.5114/jcb.2018.73994

eISSN: 2081-2841
ISSN: 1689-832X

Journal of Contemporary Brachytherapy

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Original paper

Accelerated partial breast irradiation in a single 18 Gy fraction with high-dose-rate brachytherapy: preliminary results

Javier Anchuelo Latorre

,

Piedad Galdós

,

Lucía Alonso Buznego

,

Ana García Blanco

,

Juan Cardenal

,

María Ferri

,

Iván Díaz de Cerio

,

Elisabet Arrojo

,

Nicolás Sierrasesúmaga

,

Mónica González Noriega

,

Ana De Juan Ferré

,

Rosa Fabregat

,

Samuel Ruíz

,

Pedro J. Prada

J Contemp Brachytherapy 2018; 10, 1: 58–63

DOI: https://doi.org/10.5114/jcb.2018.73994

Online publish date: 2018/02/28

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AMA

Latorre J, Galdós P, Buznego L, et al. Accelerated partial breast irradiation in a single 18 Gy fraction with high-dose-rate brachytherapy: preliminary results. Journal of Contemporary Brachytherapy. 2018;10(1):58-63. doi:10.5114/jcb.2018.73994.

APA

Latorre, J., Galdós, P., Buznego, L., Blanco, A., Cardenal, J.,  & Ferri, M. et al. (2018). Accelerated partial breast irradiation in a single 18 Gy fraction with high-dose-rate brachytherapy: preliminary results. Journal of Contemporary Brachytherapy, 10(1), 58-63. https://doi.org/10.5114/jcb.2018.73994

Chicago

Latorre, Javier Anchuelo, Piedad Galdós, Lucía Alonso Buznego, Ana García Blanco, Juan Cardenal, María Ferri,  and Iván Díaz de Cerio et al. 2018. "Accelerated partial breast irradiation in a single 18 Gy fraction with high-dose-rate brachytherapy: preliminary results". Journal of Contemporary Brachytherapy 10 (1): 58-63. doi:10.5114/jcb.2018.73994.

Harvard

Latorre, J., Galdós, P., Buznego, L., Blanco, A., Cardenal, J., Ferri, M., Cerio, I., Arrojo, E., Sierrasesúmaga, N., Noriega, M., Ferré, A., Fabregat, R., Ruíz, S.,  and Prada, P. (2018). Accelerated partial breast irradiation in a single 18 Gy fraction with high-dose-rate brachytherapy: preliminary results. Journal of Contemporary Brachytherapy, 10(1), pp.58-63. https://doi.org/10.5114/jcb.2018.73994

MLA

Latorre, Javier Anchuelo et al. "Accelerated partial breast irradiation in a single 18 Gy fraction with high-dose-rate brachytherapy: preliminary results." Journal of Contemporary Brachytherapy, vol. 10, no. 1, 2018, pp. 58-63. doi:10.5114/jcb.2018.73994.

Vancouver

Latorre J, Galdós P, Buznego L, Blanco A, Cardenal J, Ferri M et al. Accelerated partial breast irradiation in a single 18 Gy fraction with high-dose-rate brachytherapy: preliminary results. Journal of Contemporary Brachytherapy. 2018;10(1):58-63. doi:10.5114/jcb.2018.73994.

Introduction
To evaluate the feasibility of acute and chronic toxicity in patients suitable for accelerated partial breast irradiation (APBI) in a single 18 Gy fraction with multicatheter high-dose-rate (HDR) brachytherapy, as well as cosmetic and oncological outcomes.

Material and methods
Between September 2014 and March 2016, twenty consecutive patients with low-risk invasive and ductal carcinoma in situ were treated with interstitial multicatheter HDR brachytherapy in a single 18 Gy fraction.

Results
Median age was 63.5 years (range, 51-79). Acute toxicity was observed in seven patients, while the pain during following days and hematoma were seen in four patients. With a median follow-up of 24 months, late toxicity was found in one patient with fat necrosis g2 and fibrosis g2 in another patient. The overall survival (OS) and locoregional control (LC) was 100%. Disease-free survival (DFS) and distant control was 95%. Good to excellent cosmetic outcomes were noted in 80% of patients and fair in 4 patients (20%).

Conclusions
This is the first report in the medical literature that focuses on feasibility and acute and chronic toxicity, with a median follow-up of 24 months (range, 20-40). The protocol is viable and convenient. However, a longer follow-up is needed to know chronic toxicity and oncologic outcomes.

keywords:

Accelerated partial breast irradiation in a single 18 Gy fraction with high-dose-rate brachytherapy: preliminary results

Javier Anchuelo Latorre , Piedad Galdós , Lucía Alonso Buznego , Ana García Blanco , Juan Cardenal , María Ferri , Iván Díaz de Cerio , Elisabet Arrojo , Nicolás Sierrasesúmaga , Mónica González Noriega , Ana De Juan Ferré , Rosa Fabregat , Samuel Ruíz , Pedro J. Prada

APBI, brachytherapy, breast cancer, morbidity