eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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5/2019
vol. 36
 
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abstract:
Original paper

Analysis of serum chemerin concentrations in psoriatic patients in relation to metabolic abnormalities

Katarzyna M. Chyl-Surdacka
1
,
Agnieszka Gerkowicz
1
,
Joanna Bartosińska
1
,
Małgorzata Kowal
1
,
Joanna Przepiórka-Kosińska
1
,
Gabriel Surdacki
2
,
Dorota Krasowska
1
,
Grażyna Chodorowska
1

  1. Department of Dermatology, Venereology and Paediatric Dermatology, Medical University of Lublin, Lublin, Poland
  2. Department of Urology and Urological Oncology, John of God Regional Hospital, Lublin, Poland
Adv Dermatol Allergol 2019; XXXVI (5): 531-537
DOI: https://doi.org/10.5114/ada.2019.89503
Online publish date: 2019/11/12
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Introduction
Recent data depict psoriasis as a systemic disease with many comorbidities, especially metabolic syndrome and cardiovascular diseases. Chemerin, an adipokine secreted by adipose tissue cells, may prove to be an important link between psoriasis and its comorbidities.

Aim
Assessment of serum concentrations of chemerin in patients with psoriasis and the healthy control group as well as evaluation of a possible correlation between adipokine concentrations and selected psoriasis severity indices and metabolic syndrome components.

Material and methods
One hundred and two patients with diagnosed psoriasis and 40 healthy volunteers were enrolled in the study. In all subjects, serum chemerin concentrations and selected metabolic syndrome components including lipid and glucose levels were determined. Psoriasis severity was assessed using the PASI and BSA indices.

Results
A higher concentration of chemerin was demonstrated in the group of psoriasis patients compared to the control group (p < 0.05). A positive correlation between chemerin concentration and C-reactive protein concentration (p = 0.001), body mass index (p = 0.031) and triglyceride concentration (p = 0.043) was found. An inverse correlation with high-density lipoprotein cholesterol concentrations (p = 0.015) was also noted. Significantly higher concentrations of chemerin were observed in psoriatic patients with elevated low-density lipoptotein (LDL) cholesterol levels in comparison with patients with normal LDL values (p = 0.032). Chemerin concentrations were also significantly higher in patients with both psoriasis and elevated glucose levels compared to patients with normal blood glucose values (p = 0.043).

Conclusions
The results obtained suggest a possible role of chemerin as an adipokine linking psoriasis with metabolic syndrome.

keywords:

chemerin, adipokines, metabolic syndrome, psoriasis
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