Antigen recognition in the pathogenesis of immunoglobulin A-related autoimmune bullous diseases

Zhiliang Li; Ke Jing; Suo Li; Suying Feng

doi:10.5114/ada.2018.77663

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Review paper

Antigen recognition in the pathogenesis of immunoglobulin A-related autoimmune bullous diseases

Zhiliang Li

,

Ke Jing

,

Suo Li

,

Suying Feng

Adv Dermatol Allergol 2018; XXXV (4): 338–343

DOI: https://doi.org/10.5114/ada.2018.77663

Online publish date: 2018/08/21

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Immunoglobulin A (IgA) is the most common subtype of antibodies in mucosal surfaces. In most of autoimmune bullous diseases, however, immunoglobulin G (IgG) is the main pathogenic antibody that plays a role through complementation. The IgA antibody for epidermal connection protein can be found in the sera of some patients with blistering skin disease. Of these patients, some have the IgA antibody in their sera, while others have IgG and IgA antibodies. IgA-related autoimmune bullous diseases are less common in clinical practice. In the past, these diseases were not fully understood and their classifications were confusing. Recently, some progress has been made in the study of these diseases.

keywords:

Antigen recognition in the pathogenesis of immunoglobulin A-related autoimmune bullous diseases

Zhiliang Li , Ke Jing , Suo Li , Suying Feng

immunoglobulin A, autoimmune bullous disease

Zhiliang Li

,

Ke Jing

,

Suo Li

,

Suying Feng