eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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1/2024
vol. 41
 
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abstract:
Original paper

B-ultrasound or CT-guided 3D-printing individualized non-coplanar template brachytherapy for the treatment of locally uncontrolled recurrent head and neck squamous cell carcinoma

Pengbing Han
1
,
Fengju Li
1
,
Yanping Zhang
1
,
Liying Gao
1
,
Guiqiong Zhang
1
,
Qing Guo
1
,
Yuxia Zhu
1
,
Qun Su
1

  1. Department of Radiotherapy, Gansu Provincial Cancer Hospital, Lanzhou, China
Adv Dermatol Allergol 2024; XLI (1): 41-48
DOI: https://doi.org/10.5114/ada.2024.136252
Online publish date: 2024/03/15
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Introduction:
It is worth to explore a more effective treatment method to minimize the damage for patients during the treatment process.

Aim:
To explore the method, feasibility and efficacy of B-ultrasound or computed tomography (CT)-guided 3D printing individualized non-coplanar template brachytherapy in the treatment of locally uncontrolled recurrent head and neck squamous cell carcinoma.

Material and methods:
Ten patients with locally uncontrolled recurrent head and neck squamous cell carcinoma who were treated in our department from August 2021 to February 2023 were collected and treated by 3D printing individualized non-coplanar template brachytherapy under the guidance of B-ultrasound or CT, using the 192Ir high-dose rate afterloading treatment machine of NUCLETRON Technologies GmbH. The radiation source was 192Ir, with a diameter of 0.5 mm, a length of 3.5 mm, a total dose of 10–24 Gy, 5–8 Gy/time, once a week.

Results:
According to the efficacy evaluation criteria, CT scan was performed after 1-6 months, followed up for 24 months, including CR 40% (4/10), PR 50% (5/10), NC 10% (5/10), PD 0 (0). The total effective rate of CR + PR was 90% (9/10), the 6-month local control rate was 90%, the 12-month local control rate was 80%, the 18-month local control rate was 70%, and the 24-month local control rate was 70%. The overall survival rate at 24 months was 100%.

Conclusions:
Safe and effective interpolation is used to guide the 3D printing of a single non-coplanar template with B-ultrasound or CT in the radiotherapy of local and uncontrolled recurrent head and neck squamous cell carcinoma. According to the guidance of B-ultrasound or CT, the 3D printing individualized non-coplanar template has an obvious healing effect especially in the brachytherapy, and can also protect the functional organs well, with less side effects and fewer complications. Therefore, this method is the most effective for the treatment of locally uncontrolled recurrent head and neck squamous cell carcinoma.

keywords:

3D printing, close inter-tissue transplantation, local uncontrolled recurrence, squamous cell carcinoma of the head and neck
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