eISSN: 1896-9151
ISSN: 1734-1922
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1/2008
vol. 4
 
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Case report
Coronaviruses OC43 and 229E lower respiratory tract co-infections: a clinical report of two cases

Maria Eboriadou
,
Katerina Haidopoulou
,
Panagiota Xanthou
,
Anna Papa

Arch Med Sci 2008; 4, 1: 88–90
Online publish date: 2008/04/07
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We report two cases of hospitalized children with human coronavirus (HCoV) co-infection. The first patient was a 6-month female infant admitted for acute bronchiolitis with serologically confirmed respiratory syncytial virus (RSV) infection, while the second one was a 7-year old boy with serologically confirmed Mycoplasma pneumoniae infection. HCoV-OC43 and HCoV-229E were detected in nasopharyngeal aspirate samples of the patients respectively using reverse transcriptase-polymerase chain reaction (RT-PCR). Both children recovered uneventfully. HCoV-229E and HCoV-OC43 usually cause upper respiratory infections; however, rarely, they are associated with lower respiratory tract infection. We discuss their possible role as a co-infectious agent in lower respiratory tract infection.
keywords:

coronavirus, respiratory syncytial virus, Mycoplasma pneumoniae, lower respiratory tract infection
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