Changes of Langerhans cells during skin ageing

Barbara Zegarska; Katarzyna Pietkun; Paulina Giemza-Kucharska; Tomasz Zegarski; Maciej S. Nowacki; Krystyna Romańska-Gocka

doi:10.5114/ada.2017.67849

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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3/2017
vol. 34

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abstract:

Original paper

Changes of Langerhans cells during skin ageing

Barbara Zegarska

,

Katarzyna Pietkun

,

Paulina Giemza-Kucharska

,

Tomasz Zegarski

,

Maciej S. Nowacki

,

Krystyna Romańska-Gocka

Adv Dermatol Allergol 2017; XXXIV (3): 260-267

DOI: https://doi.org/10.5114/ada.2017.67849

Online publish date: 2017/05/29

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Introduction: During the process of skin ageing, changes occur in all skin layers and all cells, including the Langerhans cells.

Aim: To assess whether any quantitative difference in the number of CD1a+ LC cells/mm² and HLA-DR+ LC cells/mm² as well as in their morphological features can be observed during the course of different types of skin ageing.

Material and methods: The study was conducted in a group of 60 women, which was divided into three independent groups: group I with symptoms of menopausal skin ageing, group II with symptoms of photoageing, group III with symptoms of chronological ageing. Skin biopsy samples were taken from the pre-auricular region from all of the participants. The number of CD1a+ LC cells/mm² and HLA-DR+ LC cells/mm² as well as their morphological features were evaluated.

Results: The frequency of CD1a+ LC and HLA-DR+ LC in all the studied groups was diverse. In groups I and III, the LC with large cell bodies and long, multi-branched processes were the majority. In group II, the LC had small cell bodies and their processes were mainly short and unbranched.

Conclusions: The obtained results indicate the presence of quantitative and morphological changes of the CD1a+ LC and HLA-DR+ LC during the course of different types of skin ageing.

keywords:

Changes of Langerhans cells during skin ageing

Barbara Zegarska , Katarzyna Pietkun , Paulina Giemza-Kucharska , Tomasz Zegarski , Maciej S. Nowacki , Krystyna Romańska-Gocka

skin ageing, Langerhans cells, cells distribution

Barbara Zegarska

,

Katarzyna Pietkun

,

Paulina Giemza-Kucharska

,

Tomasz Zegarski

,

Maciej S. Nowacki

,

Krystyna Romańska-Gocka