eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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3/2022
vol. 39
 
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Letter to the Editor

Chronic urticaria reveals JAK2V617F positive essential thrombocythemia

Marcello Albanesi
1, 2
,
Marco Zurlo
1
,
Stefania Magistà
1
,
Nada Chaoul
1
,
Elena Minenna
2
,
Francesco Satriano
1
,
Danilo Di Bona
1
,
Eustachio Nettis
1
,
Maria Filomena Caiaffa
2
,
Luigi Macchia
1

  1. Department of Emergency and Organ Transplantation, School and Chair of Allergology and Clinical Immunology, University of Bari-Aldo Moro, Bari, Italy
  2. Department of Medical and Surgical Sciences, School and Chair of Allergology and Clinical Immunology, University of Foggia, Foggia, Italy
Adv Dermatol Allergol 2022; XXXIX (3): 642-644
DOI: https://doi.org/10.5114/ada.2021.110252
Online publish date: 2021/10/25
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Urticaria is characterized by recurrent itchy wheals and/or angioedema and is usually classified as chronic urticaria (CU), if clinical symptoms persist for more than 6 weeks. In spontaneous CU, by definition, no specific triggers are associated with the appearance of signs and symptoms.

One of the main underlying mechanisms responsible for urticaria is the activation of skin mast cells, which release histamine and other pro-inflammatory mediators involved in wheal formation and itch [1]. Aside from mast cells, other histamine-bearing cells exist, such as basophils, endothelial cells, gut cells, brain cells, smooth muscle cells and platelets. In particular, platelets contain a broad range of biological mediators: preformed mediators, such as histamine and serotonin, and newly formed mediators, such as platelet activating factor (PAF), leukotrienes and prostaglandins [2].
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