eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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SCImago Journal & Country Rank
2/2018
vol. 35
 
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abstract:
Review paper

Clinicopathologic retrospective analysis of blastic plasmacytoid dendritic cell neoplasms

Agnieszka Owczarczyk-Saczonek
,
Małgorzata Sokołowska-Wojdyło
,
Berenika Olszewska
,
Marta Malek
,
Aleksandra Znajewska-Pander
,
Anna Kowalczyk
,
Wojciech Biernat
,
Grażyna Poniatowska-Broniek
,
Wanda Knopińska-Posłuszny
,
Zygmunt Kozielec
,
Roman Nowicki
,
Waldemar Placek

Adv Dermatol Allergol 2018; XXXV (2): 128-138
Online publish date: 2018/04/24
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Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is one of the aggressive rare hematopoietic malignancies with predilection to the skin, primarily found in adults. The precise incidence of BPDCN is difficult to estimate due to constantly changing nomenclature and lack of precise defining criteria prior to the 2008 WHO classification system. There are not many cases described in the literature, what makes the diagnostic process challenging. Skin lesions such as erythematous infiltrates and nodules are usually the first manifestation of the disease. Therefore, in doubtful diagnostic cases, dermatologists should perform histopathological and immunohistochemistry examinations along with hematological and oncological cooperation, as early diagnosis and appropriate treatment is essential for improvement of the disease course. This analysis, despite the small number of patients may provide useful information on the clinical and histopathological features of this rare malignancy.
keywords:

blastic plasmacytoid dendritic cell neoplasm, CD4, CD56

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