Comparison of positive pressure extubation with traditional extubation in critically ill patients – a randomised control study

Ajeetviswanath Thanjavur Prabhakaran; Darlong Vanalal; Kapil Soni; Dalim Baidya; Richa Aggarwal; Harsha Binu; Shivanand Gamanagatti; Maya Dehran; Anjan Trikha

doi:10.5114/ait.2023.125584

eISSN: 1731-2531
ISSN: 1642-5758

Anaesthesiology Intensive Therapy

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abstract:

Original article

Comparison of positive pressure extubation with traditional extubation in critically ill patients – a randomised control study

Ajeetviswanath Thanjavur Prabhakaran

¹

,

Darlong Vanalal

¹

,

Kapil Dev Soni

²

,

Dalim Kumar Baidya

¹

,

Richa Aggarwal

²

,

Harsha Binu

¹

,

Shivanand Gamanagatti

³

,

Maya Dehran

¹

,

Anjan Trikha

¹

Department of Anesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India
Critical and Intensive Care, JPN Apex Trauma Center, All India Institute of Medical Sciences, New Delhi, India
Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India

Anaesthesiol Intensive Ther 2023; 55, 1: 38–45

DOI: https://doi.org/10.5114/ait.2023.125584

Online publish date: 2023/03/14

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AMA

Prabhakaran A, Vanalal D, Soni KD, et al. Comparison of positive pressure extubation with traditional extubation in critically ill patients – a randomised control study. Anaesthesiology Intensive Therapy. 2023;55(1):38-45. doi:10.5114/ait.2023.125584.

APA

Prabhakaran, A., Vanalal, D., Soni, K. D., Baidya, D. K., Aggarwal, R.,  & Binu, H. et al. (2023). Comparison of positive pressure extubation with traditional extubation in critically ill patients – a randomised control study. Anaesthesiology Intensive Therapy, 55(1), 38-45. https://doi.org/10.5114/ait.2023.125584

Chicago

Prabhakaran, Ajeetviswanath Thanjavur, Darlong Vanalal, Kapil D Soni, Dalim K Baidya, Richa Aggarwal, Harsha Binu,  and Shivanand Gamanagatti et al. 2023. "Comparison of positive pressure extubation with traditional extubation in critically ill patients – a randomised control study". Anaesthesiology Intensive Therapy 55 (1): 38-45. doi:10.5114/ait.2023.125584.

Harvard

Prabhakaran, A., Vanalal, D., Soni, K., Baidya, D., Aggarwal, R., Binu, H., Gamanagatti, S., Dehran, M.,  and Trikha, A. (2023). Comparison of positive pressure extubation with traditional extubation in critically ill patients – a randomised control study. Anaesthesiology Intensive Therapy, 55(1), pp.38-45. https://doi.org/10.5114/ait.2023.125584

MLA

Prabhakaran, Ajeetviswanath Thanjavur et al. "Comparison of positive pressure extubation with traditional extubation in critically ill patients – a randomised control study." Anaesthesiology Intensive Therapy, vol. 55, no. 1, 2023, pp. 38-45. doi:10.5114/ait.2023.125584.

Vancouver

Prabhakaran A, Vanalal D, Soni K, Baidya D, Aggarwal R, Binu H et al. Comparison of positive pressure extubation with traditional extubation in critically ill patients – a randomised control study. Anaesthesiology Intensive Therapy. 2023;55(1):38-45. doi:10.5114/ait.2023.125584.

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Background:
Two extubation methods are commonly used in the intensive care unit (ICU): the traditional method with endotracheal suctioning and the positive- pressure method without suctioning. Better physiological outcomes were found in lab studies using the latter, as the air passing between the endotracheal tube and the larynx pushes out the collected subglottic secretions, which can be suctioned.

Methods:
70 mechanically ventilated patients in a tertiary ICU were randomised into 2 groups of 35 patients each. At the end of the spontaneous breathing trial (SBT), the positive pressure extubation (PPE) group was given a pressure support of 15 cm H₂O and a positive end expiratory pressure of 10 cm H₂O for 5 minutes while the other group (traditional extubation – TE) was extubated directly. We compared the lung ultrasound scores (LUS), chest X-ray findings, alveolar arterial oxygen gradient changes, adverse clinical events, ICU-free days and reintubation rates between the two groups.

Results:
Median LUS at the end of the SBT was similar between the two groups. However, the median post-extubation LUS at 30 minutes, 6 hours, 24 hours in the PPE group [5 (4–8) (P = 0.04), 5 (3–8) (P = 0.02), 4 (3–7) (P = 0.02), respectively] were significantly lower compared to the TE group [6 (6–8), 6 (5–7.5), 6 (5–7.5), respectively]. There was a persistent lowering of the scores even at the end of 24 hours in the PPE group, while the percentage of patients without adverse clinical events was significantly higher (80% vs. 57.14%, P = 0.04).

Conclusions:
The study shows that positive pressure extubation is a safe procedure which improves aeration and reduces adverse events.

keywords:

Comparison of positive pressure extubation with traditional extubation in critically ill patients – a randomised control study

Ajeetviswanath Thanjavur Prabhakaran 1 , Darlong Vanalal 1 , Kapil Dev Soni 2 , Dalim Kumar Baidya 1 , Richa Aggarwal 2 , Harsha Binu 1 , Shivanand Gamanagatti 3 , Maya Dehran 1 , Anjan Trikha 1

mechanical ventilation, lung ultrasound, positive pressure extubation, traditional extubation

Ajeetviswanath Thanjavur Prabhakaran

¹

,

Darlong Vanalal

¹

,

Kapil Dev Soni

²

,

Dalim Kumar Baidya

¹

,

Richa Aggarwal

²

,

Harsha Binu

¹

,

Shivanand Gamanagatti

³

,

Maya Dehran

¹

,

Anjan Trikha

¹