Computed tomography-guided implantation of <sup>125</sup>I seeds brachytherapy for recurrent multiple pulmonary oligometastases: initial experience and results

Jie Li; Lijuan Zhang; Wenhuan Xu; Teng Wang; Leyuan Zhou; Qigen Xie; Weiguo Wang; Yanyan Hua

doi:10.5114/jcb.2017.67023

eISSN: 2081-2841
ISSN: 1689-832X

Journal of Contemporary Brachytherapy

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2/2017
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abstract:

Original paper

Computed tomography-guided implantation of ¹²⁵I seeds brachytherapy for recurrent multiple pulmonary oligometastases: initial experience and results

Jie Li

,

Lijuan Zhang

,

Wenhuan Xu

,

Teng Wang

,

Leyuan Zhou

,

Qigen Xie

,

Weiguo Wang

,

Yanyan Hua

J Contemp Brachytherapy 2017; 9, 2: 132–138

DOI: https://doi.org/10.5114/jcb.2017.67023

Online publish date: 2017/04/03

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AMA

Li J, Zhang L, Xu W, et al. Computed tomography-guided implantation of 125I seeds brachytherapy for recurrent multiple pulmonary oligometastases: initial experience and results. Journal of Contemporary Brachytherapy. 2017;9(2):132-138. doi:10.5114/jcb.2017.67023.

APA

Li, J., Zhang, L., Xu, W., Wang, T., Zhou, L.,  & Xie, Q. et al. (2017). Computed tomography-guided implantation of 125I seeds brachytherapy for recurrent multiple pulmonary oligometastases: initial experience and results. Journal of Contemporary Brachytherapy, 9(2), 132-138. https://doi.org/10.5114/jcb.2017.67023

Chicago

Li, Jie, Lijuan Zhang, Wenhuan Xu, Teng Wang, Leyuan Zhou, Qigen Xie,  and Weiguo Wang et al. 2017. "Computed tomography-guided implantation of 125I seeds brachytherapy for recurrent multiple pulmonary oligometastases: initial experience and results". Journal of Contemporary Brachytherapy 9 (2): 132-138. doi:10.5114/jcb.2017.67023.

Harvard

Li, J., Zhang, L., Xu, W., Wang, T., Zhou, L., Xie, Q., Wang, W.,  and Hua, Y. (2017). Computed tomography-guided implantation of 125I seeds brachytherapy for recurrent multiple pulmonary oligometastases: initial experience and results. Journal of Contemporary Brachytherapy, 9(2), pp.132-138. https://doi.org/10.5114/jcb.2017.67023

MLA

Li, Jie et al. "Computed tomography-guided implantation of 125I seeds brachytherapy for recurrent multiple pulmonary oligometastases: initial experience and results." Journal of Contemporary Brachytherapy, vol. 9, no. 2, 2017, pp. 132-138. doi:10.5114/jcb.2017.67023.

Vancouver

Li J, Zhang L, Xu W, Wang T, Zhou L, Xie Q et al. Computed tomography-guided implantation of 125I seeds brachytherapy for recurrent multiple pulmonary oligometastases: initial experience and results. Journal of Contemporary Brachytherapy. 2017;9(2):132-138. doi:10.5114/jcb.2017.67023.

Purpose: To retrospectively evaluate the efficacy and safety of computed tomography (CT)-guided percutaneous interstitial brachytherapy using ¹²⁵I radioactive seeds for multiple pulmonary metastatic tumors.

Material and methods: Between September 2013 and December 2015, 22 patients with multiple pulmonary metastases, who after conventional chemotherapy and trans-arterial chemoembolization (TACE) therapy were considered unable to withstand stereotactic body radiation therapy (SBRT), received CT-guided ¹²⁵I brachytherapy. Clinical data were studied retrospectively. A planning target volume of 90% (D90) was 120-160 Gy for ¹²⁵I seeds with an activity of 25.9 MBq. A CT-based evaluation performed 1, 2, and 6 months’ post-implantation enabled review of local control of tumors.

Results: Twenty-two patients with 65 pulmonary metastases successfully completed treatment. The mean value for D90 for implantation for ¹²⁵I seeds was 132 Gy. Complete response (CR) + partial response (PR) was documented in 81.54%, 78.46%, and 78.46% of patients at 1, 2, and 6 months after implantation, respectively. Fourteen out of 22 patients had CR, 3 had PR, 2 had stable disease (SD), and 3 had progressive disease (PD). Most of the metastases (CR + PR + SD; 87.69% after 6 months) were controlled by implantation.

Conclusions: CT-guided ¹²⁵I brachytherapy is a safe and effective treatment for multiple pulmonary metastatic tumors, and can achieve good short-term local control, so long as the radiation dose is sufficient.

keywords:

Computed tomography-guided implantation of 125I seeds brachytherapy for recurrent multiple pulmonary oligometastases: initial experience and results

Jie Li , Lijuan Zhang , Wenhuan Xu , Teng Wang , Leyuan Zhou , Qigen Xie , Weiguo Wang , Yanyan Hua

brachytherapy, computed tomography, 125I, pulmonary metastatic tumors

Computed tomography-guided implantation of ¹²⁵I seeds brachytherapy for recurrent multiple pulmonary oligometastases: initial experience and results

Jie Li

,

Lijuan Zhang

,

Wenhuan Xu

,

Teng Wang

,

Leyuan Zhou

,

Qigen Xie

,

Weiguo Wang

,

Yanyan Hua

brachytherapy, computed tomography, ¹²⁵I, pulmonary metastatic tumors