Correlations of post-implant regional dosimetric parameters at 24 hours and one month, with clinical results of low-dose-rate brachytherapy for localized prostate cancer

Eiichiro Okazaki; Katsuyuki Kuratsukuri; Kentaro Ishii; Tomoaki Tanaka; Ryo Ogino; Tomohiro Nishikawa; Hideyuki Morimoto; Masako Hosono; Yukio Miki

doi:10.5114/jcb.2017.72547

eISSN: 2081-2841
ISSN: 1689-832X

Journal of Contemporary Brachytherapy

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abstract:

Original paper

Correlations of post-implant regional dosimetric parameters at 24 hours and one month, with clinical results of low-dose-rate brachytherapy for localized prostate cancer

Eiichiro Okazaki

,

Katsuyuki Kuratsukuri

,

Kentaro Ishii

,

Tomoaki Tanaka

,

Ryo Ogino

,

Tomohiro Nishikawa

,

Hideyuki Morimoto

,

Masako Hosono

,

Yukio Miki

J Contemp Brachytherapy 2017; 9, 6: 499–507

DOI: https://doi.org/10.5114/jcb.2017.72547

Online publish date: 2017/12/30

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AMA

Okazaki E, Kuratsukuri K, Ishii K, et al. Correlations of post-implant regional dosimetric parameters at 24 hours and one month, with clinical results of low-dose-rate brachytherapy for localized prostate cancer. Journal of Contemporary Brachytherapy. 2017;9(6):499-507. doi:10.5114/jcb.2017.72547.

APA

Okazaki, E., Kuratsukuri, K., Ishii, K., Tanaka, T., Ogino, R.,  & Nishikawa, T. et al. (2017). Correlations of post-implant regional dosimetric parameters at 24 hours and one month, with clinical results of low-dose-rate brachytherapy for localized prostate cancer. Journal of Contemporary Brachytherapy, 9(6), 499-507. https://doi.org/10.5114/jcb.2017.72547

Chicago

Okazaki, Eiichiro, Katsuyuki Kuratsukuri, Kentaro Ishii, Tomoaki Tanaka, Ryo Ogino, Tomohiro Nishikawa,  and Hideyuki Morimoto et al. 2017. "Correlations of post-implant regional dosimetric parameters at 24 hours and one month, with clinical results of low-dose-rate brachytherapy for localized prostate cancer". Journal of Contemporary Brachytherapy 9 (6): 499-507. doi:10.5114/jcb.2017.72547.

Harvard

Okazaki, E., Kuratsukuri, K., Ishii, K., Tanaka, T., Ogino, R., Nishikawa, T., Morimoto, H., Hosono, M.,  and Miki, Y. (2017). Correlations of post-implant regional dosimetric parameters at 24 hours and one month, with clinical results of low-dose-rate brachytherapy for localized prostate cancer. Journal of Contemporary Brachytherapy, 9(6), pp.499-507. https://doi.org/10.5114/jcb.2017.72547

MLA

Okazaki, Eiichiro et al. "Correlations of post-implant regional dosimetric parameters at 24 hours and one month, with clinical results of low-dose-rate brachytherapy for localized prostate cancer." Journal of Contemporary Brachytherapy, vol. 9, no. 6, 2017, pp. 499-507. doi:10.5114/jcb.2017.72547.

Vancouver

Okazaki E, Kuratsukuri K, Ishii K, Tanaka T, Ogino R, Nishikawa T et al. Correlations of post-implant regional dosimetric parameters at 24 hours and one month, with clinical results of low-dose-rate brachytherapy for localized prostate cancer. Journal of Contemporary Brachytherapy. 2017;9(6):499-507. doi:10.5114/jcb.2017.72547.

Purpose: To evaluate the correlations of post-implant regional dosimetrics at 24 hours (24 h) and 1 month after implant procedures, with clinical outcomes of low-dose-rate (LDR) brachytherapy for localized prostate cancer.

Material and methods: Between January 2008 and December 2014, 130 consecutive patients treated for localized prostate cancer, receiving definitive iodine-125 (¹²⁵I) brachytherapy treatment were retrospectively analyzed. All patients underwent post-implant CT imaging for dosimetric analysis at 24 h and 1 month after implantation procedure. Prostate contours were divided into quadrants: anterior-superior (ASQ), posterior-superior (PSQ), anterior-inferior (AIQ), and posterior-inferior (PIQ). Predictive factors and cut-off values of biochemical failure-free survival (BFFS) and toxicities of LDR brachytherapy were analyzed.

Results: The median follow-up time was 69.5 months. Seven patients (5.4%) had biochemical failure. The 3-year and 5-year BFFS rates were 96.7% and 93.1%, respectively. On multivariate analysis, prostate-specific antigen and Gleason score were significant prognostic factors for biochemical failure. D₉₀ (the minimal dose received by 90% of the volume) of PSQ and PIQ at 24 h, and D₉₀ of PSQ at 1 month were also significant factors. The cut-off values of PSQ D₉₀ were 145 Gy at 24 h and 160 Gy at 1 month. D₉₀ of the whole prostate was not significant at 24 h and at 1 month. D₉₀ of PSQ at 1 month was a significant factor for rectal hemorrhage.

Conclusions: Post-implant D₉₀ of PSQ is significantly associated with BFFS for localized prostate cancer not only at 1 month, but also at 24 hours. D₉₀ of PSQ at 1 month is also a significant factor for rectal hemorrhage.

keywords:

Correlations of post-implant regional dosimetric parameters at 24 hours and one month, with clinical results of low-dose-rate brachytherapy for localized prostate cancer

Eiichiro Okazaki , Katsuyuki Kuratsukuri , Kentaro Ishii , Tomoaki Tanaka , Ryo Ogino , Tomohiro Nishikawa , Hideyuki Morimoto , Masako Hosono , Yukio Miki

brachytherapy, low-dose-rate, prostate cancer, seeds

Eiichiro Okazaki

,

Katsuyuki Kuratsukuri

,

Kentaro Ishii

,

Tomoaki Tanaka

,

Ryo Ogino

,

Tomohiro Nishikawa

,

Hideyuki Morimoto

,

Masako Hosono

,

Yukio Miki