Coverage with dosimetric concordance index (CDCI): a tool for evaluating dosimetric impact of inter-observer target variability in brachytherapy

Ritu Raj Upreti; Ashwini Budrukkar; Udita Upreti; Tabassum Wadasadawala; Rima Pathak; Shagun Misra; Lavanya Gurrum; Rajesh Kinhikar; Deepak Deshpande

doi:10.5114/jcb.2020.94309

eISSN: 2081-2841
ISSN: 1689-832X

Journal of Contemporary Brachytherapy

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abstract:

Original paper

Coverage with dosimetric concordance index (CDCI): a tool for evaluating dosimetric impact of inter-observer target variability in brachytherapy

Ritu Raj Upreti

^{1, 2}

,

Ashwini Budrukkar

^{2, 3}

,

Udita Upreti

¹

,

Tabassum Wadasadawala

^{2, 4}

,

Rima Pathak

^{2, 3}

,

Shagun Misra

³

,

Lavanya Gurrum

^{2, 3}

,

Rajesh A Kinhikar

^{1, 2}

,

Deepak D Deshpande

^{1, 2}

Department of Medical Physics, Tata Memorial Hospital, Parel, Mumbai, India
Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai, India
Department of Radiation Oncology, Tata Memorial Hospital, Parel, Mumbai, India
Department of Radiation Oncology, Advanced Centre for Treatment, Research and Education in Cancer, Kharghar, Navi Mumbai, India

J Contemp Brachytherapy 2020; 12, 2: 160–165

DOI: https://doi.org/10.5114/jcb.2020.94309

Online publish date: 2020/04/08

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AMA

Upreti R, Budrukkar A, Upreti U, et al. Coverage with dosimetric concordance index (CDCI): a tool for evaluating dosimetric impact of inter-observer target variability in brachytherapy. Journal of Contemporary Brachytherapy. 2020;12(2):160-165. doi:10.5114/jcb.2020.94309.

APA

Upreti, R., Budrukkar, A., Upreti, U., Wadasadawala, T., Pathak, R.,  & Misra, S. et al. (2020). Coverage with dosimetric concordance index (CDCI): a tool for evaluating dosimetric impact of inter-observer target variability in brachytherapy. Journal of Contemporary Brachytherapy, 12(2), 160-165. https://doi.org/10.5114/jcb.2020.94309

Chicago

Upreti, Ritu Raj, Ashwini Budrukkar, Udita Upreti, Tabassum Wadasadawala, Rima Pathak, Shagun Misra,  and Lavanya Gurrum et al. 2020. "Coverage with dosimetric concordance index (CDCI): a tool for evaluating dosimetric impact of inter-observer target variability in brachytherapy". Journal of Contemporary Brachytherapy 12 (2): 160-165. doi:10.5114/jcb.2020.94309.

Harvard

Upreti, R., Budrukkar, A., Upreti, U., Wadasadawala, T., Pathak, R., Misra, S., Gurrum, L., Kinhikar, R.,  and Deshpande, D. (2020). Coverage with dosimetric concordance index (CDCI): a tool for evaluating dosimetric impact of inter-observer target variability in brachytherapy. Journal of Contemporary Brachytherapy, 12(2), pp.160-165. https://doi.org/10.5114/jcb.2020.94309

MLA

Upreti, Ritu Raj et al. "Coverage with dosimetric concordance index (CDCI): a tool for evaluating dosimetric impact of inter-observer target variability in brachytherapy." Journal of Contemporary Brachytherapy, vol. 12, no. 2, 2020, pp. 160-165. doi:10.5114/jcb.2020.94309.

Vancouver

Upreti R, Budrukkar A, Upreti U, Wadasadawala T, Pathak R, Misra S et al. Coverage with dosimetric concordance index (CDCI): a tool for evaluating dosimetric impact of inter-observer target variability in brachytherapy. Journal of Contemporary Brachytherapy. 2020;12(2):160-165. doi:10.5114/jcb.2020.94309.

Purpose
The aim of this study was to propose an index for evaluating dosimetric impact of inter-observer target delineation variability in brachytherapy.

Material and methods
The coverage with dosimetric concordance index (CDCI) is expressed as CDCI_common and CDCI_pair. The CDCI_common is the mean coverage of target volume with common volume irradiated by prescription dose among all observers and represents the condition of worst target coverage. CDCI_pair is the generalized form of CDCI, which is mean target coverage with common prescription volume obtained between all possible pairs of observers and represents more realistic coverage of target with dosimetric concordance. The index was used to evaluate the dosimetric impact of target delineation variability in optimized conformal plans on target volumes of five radiation oncologists for twenty patients of multi-catheter interstitial partial breast brachytherapy.

Results
The mean decline of 5.6 ±3.2% and 11.3 ±5.7% in CDCI_pair and CDCI_common, respectively, was observed comparing to coverage index (CI) of target volume in all patients due to inter-observer target variability. CDCI_common and CDCI_pair were found to have significant linear correlation (r = 0.964, p < 0.000). The difference between CDC and CI increased with the mean relative target volume among observers. Significant correlation (r = 0.962, p < 0.000) was also noted for the difference (Δ) in CDCI_common and CDCI_pair with CI of target volume.

Conclusions
The recommended indices and difference between the dosimetric coverage of target volume (CI) with CDCI (∆CDCI) can be used for evaluating dosimetric impact of the inter-observer target delineation variability.

keywords:

Coverage with dosimetric concordance index (CDCI): a tool for evaluating dosimetric impact of inter-observer target variability in brachytherapy

Ritu Raj Upreti 1, 2 , Ashwini Budrukkar 2, 3 , Udita Upreti 1 , Tabassum Wadasadawala 2, 4 , Rima Pathak 2, 3 , Shagun Misra 3 , Lavanya Gurrum 2, 3 , Rajesh A Kinhikar 1, 2 , Deepak D Deshpande 1, 2

target delineation variability, dosimetric impact, spatial concordance, dosimetric indices

Ritu Raj Upreti

^{1, 2}

,

Ashwini Budrukkar

^{2, 3}

,

Udita Upreti

¹

,

Tabassum Wadasadawala

^{2, 4}

,

Rima Pathak

^{2, 3}

,

Shagun Misra

³

,

Lavanya Gurrum

^{2, 3}

,

Rajesh A Kinhikar

^{1, 2}

,

Deepak D Deshpande

^{1, 2}