Does HSP90 play an important role in psoriasis?

Rafał Czajkowski; Sebastian Kaszewski; Tadeusz Tadrowski; Dariusz Grzanka; Justyna Ziandarska; Gerard Drewa; Luiza Marek-Józefowicz

doi:10.5114/ada.2021.106210

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Original paper

Does HSP90 play an important role in psoriasis?

Rafał Czajkowski

¹

,

Sebastian Kaszewski

²

,

Tadeusz Tadrowski

¹

,

Dariusz Grzanka

³

,

Justyna Ziandarska

¹

,

Gerard Drewa

⁴

,

Luiza Marek-Józefowicz

¹

Department of Dermatology and Venerology, Faculty of Medicine, Ludwik Rydygier Medical College in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland
University Hospitals Coventry and Warwickshire NHS Trust, United Kingdom
Department of Clinical Pathomorphology, Faculty of Medicine, Ludwik Rydygier Medical College in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland
University of Bydgoszcz, Poland

Adv Dermatol Allergol 2021; XXXVIII (2): 319-326

DOI: https://doi.org/10.5114/ada.2021.106210

Online publish date: 2021/05/22

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Introduction
Psoriasis is a chronic, inflammatory skin disease. Environmental, genetic, autoinflammatory and autoimmune factors play a role in the pathogenesis of disease. It is believed that heat shock protein 90 (HSP90) is an interleukin-17 (IL-17) receptor, which plays an essential role in the psoriasis pathogenesis.

Aim
To evaluate the expression of the gene encoding HSP90 protein in keratinocytes of patients with psoriasis depending on its duration, recurrences, exacerbating factors, therapy form, and the coexistence of metabolic disorders and cardiovascular diseases.

Material and methods
Skin samples from 40 psoriatic patients were investigated in this study. Control skin biopsies were collected from 20 healthy volunteers. HSP90 expression level was measured by qRT-PCR reaction.

Results
This study has shown an increased mRNA expression of HSP90 in psoriatic patients as compared to healthy volunteers. A positive correlation of HSP90 expression and the frequency of exacerbations was found. A negative correlation between the HSP90 activity and the age of patients was demonstrated in the coexistence of psoriasis with hyperlipidaemia or diabetes. Among the factors exacerbating psoriasis, acute infections induced HSP90 expression most significantly.

Conclusions
HSP90 plays a role in the pathogenesis of psoriasis. The expression of HSP90 increases with the frequency of exacerbations of psoriasis throughout the year. Hyperlipidaemia or diabetes associated with psoriasis in young adults, and acute infections and emotional stress increase the expression of HSP90. The expression of HSP90 in psoriatic patients is not dependent on the type of psoriasis, comorbidity of cardiovascular diseases, smoking and alcohol addiction.

keywords:

Does HSP90 play an important role in psoriasis?

Rafał Czajkowski 1 , Sebastian Kaszewski 2 , Tadeusz Tadrowski 1 , Dariusz Grzanka 3 , Justyna Ziandarska 1 , Gerard Drewa 4 , Luiza Marek-Józefowicz 1

heat shock proteins, HSP90, psoriasis

Rafał Czajkowski

¹

,

Sebastian Kaszewski

²

,

Tadeusz Tadrowski

¹

,

Dariusz Grzanka

³

,

Justyna Ziandarska

¹

,

Gerard Drewa

⁴

,

Luiza Marek-Józefowicz

¹