Effectiveness and safety of secukinumab in patients
with moderate-to-severe plaque psoriasis – a real life
retrospective study

Katarzyna Galica; Aleksandra Lesiak; Magdalena Ciążyńska; Marcin Noweta; Igor Bednarski; Joanna Narbutt

doi:10.5114/ada.2020.97066

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Original paper

Effectiveness and safety of secukinumab in patients with moderate-to-severe plaque psoriasis – a real life retrospective study

Katarzyna Galica

^{1, 2}

,

Aleksandra Lesiak

¹

,

Magdalena Ciążyńska

³

,

Marcin Noweta

¹

,

Igor Bednarski

¹

,

Joanna Narbutt

¹

Department of Dermatology, Paediatric Dermatology and Oncology Clinic, Medical University of Lodz, Lodz, Poland
Chair of Oncology, Laboratory of Isotopic Fractionation in Pathological Processes, Medical University of Lodz, Lodz, Poland
Department of Proliferative Diseases, Nicolaus Copernicus Multidisciplinary Centre for Oncology and Traumatology, Lodz, Poland

Adv Dermatol Allergol 2021; XXXVIII (6): 973–978

DOI: https://doi.org/10.5114/ada.2020.97066

Online publish date: 2020/07/11

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AMA

Galica K, Lesiak A, Ciążyńska M, Noweta M, Bednarski I, Narbutt J. Effectiveness and safety of secukinumab in patients
with moderate-to-severe plaque psoriasis – a real life
retrospective study. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2021;38(6):973-978. doi:10.5114/ada.2020.97066.

APA

Galica, K., Lesiak, A., Ciążyńska, M., Noweta, M., Bednarski, I.,  & Narbutt, J. (2021). Effectiveness and safety of secukinumab in patients
with moderate-to-severe plaque psoriasis – a real life
retrospective study. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 38(6), 973-978. https://doi.org/10.5114/ada.2020.97066

Chicago

Galica, Katarzyna, Aleksandra Lesiak, Magdalena Ciążyńska, Marcin Noweta, Igor Bednarski,  and Joanna Narbutt. 2021. "Effectiveness and safety of secukinumab in patients
with moderate-to-severe plaque psoriasis – a real life
retrospective study". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 38 (6): 973-978. doi:10.5114/ada.2020.97066.

Harvard

Galica, K., Lesiak, A., Ciążyńska, M., Noweta, M., Bednarski, I.,  and Narbutt, J. (2021). Effectiveness and safety of secukinumab in patients
with moderate-to-severe plaque psoriasis – a real life
retrospective study. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 38(6), pp.973-978. https://doi.org/10.5114/ada.2020.97066

MLA

Galica, Katarzyna et al. "Effectiveness and safety of secukinumab in patients
with moderate-to-severe plaque psoriasis – a real life
retrospective study." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 38, no. 6, 2021, pp. 973-978. doi:10.5114/ada.2020.97066.

Vancouver

Galica K, Lesiak A, Ciążyńska M, Noweta M, Bednarski I, Narbutt J. Effectiveness and safety of secukinumab in patients
with moderate-to-severe plaque psoriasis – a real life
retrospective study. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2021;38(6):973-978. doi:10.5114/ada.2020.97066.

Introduction
Clinical experience indicates that secukinumab has significant efficacy in the treatment of moderate-to-severe psoriasis and psoriatic arthritis, demonstrating a rapid onset of action, sustained response, a favourable safety profile, and an improvement of patients’ quality of life.

Material and methods
To analyse the effects of skin lesions, signs and symptoms of arthritis, quality of life and safety of treatment in patients with psoriasis and psoriatic arthritis treated with secukinumab.

Results
The study included 38 subjects, 21 with psoriasis (PV) and 17 with psoriatic arthritis (PsA) who received ≥ 1 dose of secukinumab. We assessed response to secukinumab treatment by the Psoriasis Area and Severity Index (PASI), body surface area (BSA), the Dermatology Life Quality Index (DLQI), moreover in patients with PsA, we also assessed 5-point Likert scale and joint tenderness and swelling. We evaluated the safety profile of secukinumab by assessing laboratory tests and monitoring adverse reactions. Results: In patients with PV a statistically significant decrease in PASI (from 21.46 points to 0.84 point), BSA (from 22.38% to 0.8%), DLQI (from 20.57 points to 0.33 point) was observed. In patients with PsA a statistically significant decrease in PASI (from 13.41 points to 0.0 point), BSA (from 14.59% to 1.0%) and DLQI (from 17.76 points to 0.67 point) was observed. We noticed three incidences of adverse events.

Conclusions
Our results prove that secukinumab offers a good therapeutic opportunity and may be a preferred treatment option for patients with moderate-to-severe psoriasis and psoriatic arthritis. Key words: psoriasis, secukinumab, IL-17, biological treatment.

keywords:

Effectiveness and safety of secukinumab in patients with moderate-to-severe plaque psoriasis – a real life retrospective study

Katarzyna Galica 1, 2 , Aleksandra Lesiak 1 , Magdalena Ciążyńska 3 , Marcin Noweta 1 , Igor Bednarski 1 , Joanna Narbutt 1

psoriasis, secukinumab, IL-17, biological treatment

Katarzyna Galica

^{1, 2}

,

Aleksandra Lesiak

¹

,

Magdalena Ciążyńska

³

,

Marcin Noweta

¹

,

Igor Bednarski

¹

,

Joanna Narbutt

¹