Evaluation of microvessel density with CD31 and CD105 in patients with psoriasis under methotrexate and acitretin therapy

Ebru Zemheri; Ayşe Karadağ; Ilkin Zindancı; Pınar Zerk; Melike Ozturk

doi:10.5114/ada.2019.87279

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Original paper

Evaluation of microvessel density with CD31 and CD105 in patients with psoriasis under methotrexate and acitretin therapy

Ebru Zemheri

¹

,

Ayşe Serap Karadağ

²

,

Ilkin Zindancı

³

,

Pınar Engin Zerk

⁴

,

Melike Kibar Ozturk

³

Pathology Clinic, İstanbul Ümraniye Training and Research Hospital, University of Health Sciences, Istanbul, Turkey
Dermatology Clinic, Istanbul Medeniyet University, School of Medicine, Goztepe Research and Training Hospital, Istanbul, Turkey
Dermatology Clinic, İstanbul Ümraniye Training and Research Hospital, University of Health Sciences, Istanbul, Turkey
Pathology Clinic, Okmeydani Training and Research Hospital, Istanbul, Turkey

Adv Dermatol Allergol 2020; XXXVII (3): 422-427

DOI: https://doi.org/10.5114/ada.2019.87279

Online publish date: 2020/07/16

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AMA

Zemheri E, Karadağ AS, Zindancı I, Zerk PE, Ozturk MK. Evaluation of microvessel density with CD31 and CD105 in patients with psoriasis under methotrexate and acitretin therapy. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2020;37(3):422-427. doi:10.5114/ada.2019.87279.

APA

Zemheri, E., Karadağ, A. S., Zindancı, I., Zerk, P. E.,  & Ozturk, M. K. (2020). Evaluation of microvessel density with CD31 and CD105 in patients with psoriasis under methotrexate and acitretin therapy. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 37(3), 422-427. https://doi.org/10.5114/ada.2019.87279

Chicago

Zemheri, Ebru, Ayşe S Karadağ, Ilkin Zindancı, Pınar E Zerk,  and Melike K Ozturk. 2020. "Evaluation of microvessel density with CD31 and CD105 in patients with psoriasis under methotrexate and acitretin therapy". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 37 (3): 422-427. doi:10.5114/ada.2019.87279.

Harvard

Zemheri, E., Karadağ, A., Zindancı, I., Zerk, P.,  and Ozturk, M. (2020). Evaluation of microvessel density with CD31 and CD105 in patients with psoriasis under methotrexate and acitretin therapy. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 37(3), pp.422-427. https://doi.org/10.5114/ada.2019.87279

MLA

Zemheri, Ebru et al. "Evaluation of microvessel density with CD31 and CD105 in patients with psoriasis under methotrexate and acitretin therapy." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 37, no. 3, 2020, pp. 422-427. doi:10.5114/ada.2019.87279.

Vancouver

Zemheri E, Karadağ A, Zindancı I, Zerk P, Ozturk M. Evaluation of microvessel density with CD31 and CD105 in patients with psoriasis under methotrexate and acitretin therapy. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2020;37(3):422-427. doi:10.5114/ada.2019.87279.

Introduction
Methotrexate and acitretin are known to be effective in the treatment of psoriasis, but the mechanisms of the effects of these drugs are not fully known.

Aim
To investigate the effect of methotrexate and acitretin on microvessel density (MVD) in psoriasis.

Material and methods
Eighteen patients with psoriasis treated with methotrexate and 9 patients with psoriasis treated with acitretin (AT) were included in this study. MVD was evaluated immunohistochemically by using CD31 and CD105 (endoglin) antibodies.

Results
In the methotrexate group, the decrease in CD31 levels after treatment was found to be statistically significant, while in the AT group it was found to be highly significant. In both methotrexate and AT group, there was a statistically highly significant decrease in CD105 levels after treatment. There was no statistically significant difference between CD31 measurements of methotrexate and AT groups. When CD105 levels were measured before and after treatment, no statistically significant difference was found between methotrexate and AT. According to the results of CD31 changes before and after treatment, the CD31 difference was not statistically significant in both groups while the difference was higher in the AT group. CD105 differences were not statistically significant in both treatment groups before and after treatment.

Conclusions
CD31 and CD105 dyes indicate the effects of therapies on vascular proliferation and may be indicators that can be used in daily routine and follow-up studies for psoriasis.

keywords:

Evaluation of microvessel density with CD31 and CD105 in patients with psoriasis under methotrexate and acitretin therapy

Ebru Zemheri 1 , Ayşe Serap Karadağ 2 , Ilkin Zindancı 3 , Pınar Engin Zerk 4 , Melike Kibar Ozturk 3

methotrexate, acitretin, microvessel density, CD31, CD105

Ebru Zemheri

¹

,

Ayşe Serap Karadağ

²

,

Ilkin Zindancı

³

,

Pınar Engin Zerk

⁴

,

Melike Kibar Ozturk

³