Extended IgE profile of shrimp-sensitized patients based on Multiplex Examination ALEX2 – Allergy Explorer

Natalia Ukleja-Sokołowska; Kinga Lis; Marcelina Bartuzi; Magdalena Żbikowska-Gotz; Rafał Adamczak; Zbigniew Bartuzi

doi:10.5114/ada.2023.132071

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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5/2023
vol. 40

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Original paper

Extended IgE profile of shrimp-sensitized patients based on Multiplex Examination ALEX2 – Allergy Explorer

Natalia Ukleja-Sokołowska

¹

,

Kinga Lis

¹

,

Marcelina Bartuzi

²

,

Magdalena Żbikowska-Gotz

¹

,

Rafał Adamczak

³

,

Zbigniew Bartuzi

¹

Department of Allergology, Clinical Immunology and Internal Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland
Department of Gastroenterology and Nutrition Disorders, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland
Department of Obstetrics and Gynaecology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland

Adv Dermatol Allergol 2023; XL (5): 661-669

DOI: https://doi.org/10.5114/ada.2023.132071

Online publish date: 2023/10/16

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AMA

Ukleja-Sokołowska N, Lis K, Bartuzi M, Żbikowska-Gotz M, Adamczak R, Bartuzi Z. Extended IgE profile of shrimp-sensitized patients based on Multiplex Examination ALEX2 – Allergy Explorer. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2023;40(5):661-669. doi:10.5114/ada.2023.132071.

APA

Ukleja-Sokołowska, N., Lis, K., Bartuzi, M., Żbikowska-Gotz, M., Adamczak, R.,  & Bartuzi, Z. (2023). Extended IgE profile of shrimp-sensitized patients based on Multiplex Examination ALEX2 – Allergy Explorer. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 40(5), 661-669. https://doi.org/10.5114/ada.2023.132071

Chicago

Ukleja-Sokołowska, Natalia, Kinga Lis, Marcelina Bartuzi, Magdalena Żbikowska-Gotz, Rafał Adamczak,  and Zbigniew Bartuzi. 2023. "Extended IgE profile of shrimp-sensitized patients based on Multiplex Examination ALEX2 – Allergy Explorer". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 40 (5): 661-669. doi:10.5114/ada.2023.132071.

Harvard

Ukleja-Sokołowska, N., Lis, K., Bartuzi, M., Żbikowska-Gotz, M., Adamczak, R.,  and Bartuzi, Z. (2023). Extended IgE profile of shrimp-sensitized patients based on Multiplex Examination ALEX2 – Allergy Explorer. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 40(5), pp.661-669. https://doi.org/10.5114/ada.2023.132071

MLA

Ukleja-Sokołowska, Natalia et al. "Extended IgE profile of shrimp-sensitized patients based on Multiplex Examination ALEX2 – Allergy Explorer." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 40, no. 5, 2023, pp. 661-669. doi:10.5114/ada.2023.132071.

Vancouver

Ukleja-Sokołowska N, Lis K, Bartuzi M, Żbikowska-Gotz M, Adamczak R, Bartuzi Z. Extended IgE profile of shrimp-sensitized patients based on Multiplex Examination ALEX2 – Allergy Explorer. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2023;40(5):661-669. doi:10.5114/ada.2023.132071.

Introduction
The key to the correct diagnosis of shrimp allergy is a qualification to the most efficient diagnostic method and later interpretation of the result. To achieve this, it is necessary to apply a diagnostic strategy relevant to each patient’s clinical situation and approach every case individually.

Aim
In this study the allergen profile of shrimp-sensitized patients was analysed using ALEX2 Allergy Explorer.

Material and methods
This study includes 50 adult patients with positive prick-by-prick tests with tiger shrimp bought from the local eco-market and an elevated concentration of IgE specific to the shrimp allergen extract (ImmunoCap). A total of 35 patients with negative skin prick tests with shrimp and not detectable sIgE shrimp in ImmunoCap were included in the control group. All patients had ALEX2 Allergy Explorer microarray test.

Results
In the shrimp-sensitized group, 22 patients were sensitized to at least one allergen component of Penaeus monodon, 20 patients were sensitized to crab, and 20 were sensitized to lobster. Only 15 (30%) patients were sensitized to the Northern prawn (Pandalus borealis) allergen extract in ALEX2 and only 12 (24%) to Shrimp mix (Litopenaeus setiferus, Farfantepenaeus aztecus, Farfantepenaeus dourarum).

Conclusions
Sensitization to shrimp tropomyosin in the research group was present only in 34% of cases. There may be other shrimp allergen components, not available in ALEX2, which are responsible for shrimp sensitization.

keywords:

Extended IgE profile of shrimp-sensitized patients based on Multiplex Examination ALEX2 – Allergy Explorer

Natalia Ukleja-Sokołowska 1 , Kinga Lis 1 , Marcelina Bartuzi 2 , Magdalena Żbikowska-Gotz 1 , Rafał Adamczak 3 , Zbigniew Bartuzi 1

allergy, immunoglobulin E, ALEX2, shrimp, sensitization

Natalia Ukleja-Sokołowska

¹

,

Kinga Lis

¹

,

Marcelina Bartuzi

²

,

Magdalena Żbikowska-Gotz

¹

,

Rafał Adamczak

³

,

Zbigniew Bartuzi

¹