HDR-brachytherapy for accelerated partial breast irradiation: Long-term experience from a Japanese institution

Ken Yoshida; Tadayuki Kotsuma; Yuji Takaoka; Setsuo Tamenaga; Hideya Yamazaki; Takayuki Nose; Naoya Murakami; Koji Inaba; Hironori Akiyama; Koji Masui; Tadashi Takenaka; Hikaru Kubota; Nikolaos Tselis; Norikazu Masuda; Hiroyuki Yasojima; Masashi Takeda; Masayuki Mano; Satoaki Nakamura; Keita Utsunomiya; Noboru Tanigawa; Eiichi Tanaka

doi:10.5114/jcb.2023.125579

eISSN: 2081-2841
ISSN: 1689-832X

Journal of Contemporary Brachytherapy

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1/2023
vol. 15

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abstract:

Original paper

HDR-brachytherapy for accelerated partial breast irradiation: Long-term experience from a Japanese institution

Ken Yoshida

^{1, 2}

,

Tadayuki Kotsuma

^{2, 3}

,

Yuji Takaoka

^{2, 4}

,

Setsuo Tamenaga

²

,

Hideya Yamazaki

⁵

,

Takayuki Nose

⁶

,

Naoya Murakami

⁷

,

Koji Inaba

⁷

,

Hironori Akiyama

⁸

,

Koji Masui

⁹

,

Tadashi Takenaka

⁵

,

Hikaru Kubota

^{2, 10}

,

Nikolaos Tselis

¹¹

,

Norikazu Masuda

¹²

,

Hiroyuki Yasojima

¹³

,

Masashi Takeda

¹⁴

,

Masayuki Mano

¹⁵

,

Satoaki Nakamura

¹⁶

,

Keita Utsunomiya

¹

,

Noboru Tanigawa

¹⁷

,

Eiichi Tanaka

²

Department of Radiology, Kansai Medical University Medical Center, Osaka, Japan
Department of Radiation Oncology, National Hospital Organization Osaka National Hospital, Osaka, Japan
Department of Radiation Oncology, Osaka Rosai Hospital, Osaka, Japan
Department of Radiology, Saito Yukoukai Hospital, Osaka, Japan
Department of Radiology, Kyoto Prefectural University of Medicine, Kyoto, Japan
Department of Radiation Oncology, Nippon Medical School Tamanagayama Hospital, Tokyo, Japan
Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan
Department of Oral radiology, Osaka Dental University, Osaka, Japan
Department of Radiology, Fukuchiyama City Hospital, Kyoto, Japan
Division of Radiation Oncology, Kobe University Hospital, Hyogo, Japan
Department of Radiation Oncology, Johann Wolfgang Goethe University Frankfurt, Frankfurt, Germany
Department of Breast and Endocrine Surgery, Nagoya University Graduate School of Medicine, Aichi, Japan
Department of Surgery, Breast Oncology, National Hospital Organization Osaka National Hospital, Osaka, Japan
Department of Pathology, Wakakusa Daiichi Hospital, Osaka, Japan
Department of Central Laboratory and Surgical Pathology, National Hospital Organization Osaka National Hospital, Osaka, Japan
Division of Radiation Oncology, Kansai Medical University Hospital, Osaka, Japan
Department of Radiology, Kansai Medical University Hospital, Osaka, Japan

J Contemp Brachytherapy 2023; 15, 1: 1–8

DOI: https://doi.org/10.5114/jcb.2023.125579

Online publish date: 2023/02/28

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AMA

Yoshida K, Kotsuma T, Takaoka Y, et al. HDR-brachytherapy for accelerated partial breast irradiation: Long-term experience from a Japanese institution. Journal of Contemporary Brachytherapy. 2023;15(1):1-8. doi:10.5114/jcb.2023.125579.

APA

Yoshida, K., Kotsuma, T., Takaoka, Y., Tamenaga, S., Yamazaki, H.,  & Nose, T. et al. (2023). HDR-brachytherapy for accelerated partial breast irradiation: Long-term experience from a Japanese institution. Journal of Contemporary Brachytherapy, 15(1), 1-8. https://doi.org/10.5114/jcb.2023.125579

Chicago

Yoshida, Ken, Tadayuki Kotsuma, Yuji Takaoka, Setsuo Tamenaga, Hideya Yamazaki, Takayuki Nose,  and Naoya Murakami et al. 2023. "HDR-brachytherapy for accelerated partial breast irradiation: Long-term experience from a Japanese institution". Journal of Contemporary Brachytherapy 15 (1): 1-8. doi:10.5114/jcb.2023.125579.

Harvard

Yoshida, K., Kotsuma, T., Takaoka, Y., Tamenaga, S., Yamazaki, H., Nose, T., Murakami, N., Inaba, K., Akiyama, H., Masui, K., Takenaka, T., Kubota, H., Tselis, N., Masuda, N., Yasojima, H., Takeda, M., Mano, M., Nakamura, S., Utsunomiya, K., Tanigawa, N.,  and Tanaka, E. (2023). HDR-brachytherapy for accelerated partial breast irradiation: Long-term experience from a Japanese institution. Journal of Contemporary Brachytherapy, 15(1), pp.1-8. https://doi.org/10.5114/jcb.2023.125579

MLA

Yoshida, Ken et al. "HDR-brachytherapy for accelerated partial breast irradiation: Long-term experience from a Japanese institution." Journal of Contemporary Brachytherapy, vol. 15, no. 1, 2023, pp. 1-8. doi:10.5114/jcb.2023.125579.

Vancouver

Yoshida K, Kotsuma T, Takaoka Y, Tamenaga S, Yamazaki H, Nose T et al. HDR-brachytherapy for accelerated partial breast irradiation: Long-term experience from a Japanese institution. Journal of Contemporary Brachytherapy. 2023;15(1):1-8. doi:10.5114/jcb.2023.125579.

Purpose:
We investigated the long-term oncological outcome of high-dose-rate (HDR) multicatheter interstitial brachytherapy (MIB) for adjuvant accelerated partial breast irradiation (APBI) after breast conserving surgery in Japanese patients.

Material and methods:
Between June 2002 and October 2011, 86 breast cancer patients were treated at National Hospital Organization Osaka National Hospital (trial number of the local institutional review board, 0329). Median age was 48 years (range, 26-73 years). Eighty patients had invasive and 6 patients non-invasive ductal carcinoma. Tumor stage distribution was pT0 in 2, pTis in 6, pT1 in 55, pT2 in 22, and pT3 in one patient, respectively. Twenty-seven patients had close/positive resection margins. Total physical HDR dose was 36-42 Gy in 6-7 fractions.

Results:
At a median follow-up of 119 months (range, 13-189 months), the 10-year local control (LC) and overall survival rate was 93% and 88%, respectively. Concerning the 2009 Groupe Européen de Curiethérapie-European Society for Therapeutic Radiology and Oncology risk stratification scheme, the 10-year LC rate was 100%, 100%, and 91% for patients considered as low-risk, intermediate-risk, and high-risk, respectively. According to the 2018 American Brachytherapy Society risk stratification scheme, the 10-year LC rate was 100% and 90% for patients ‘acceptable’ and ‘unacceptable’ for APBI, respectively. Wound complications were observed in 7 patients (8%). Risk factors for wound complications were the omission of prophylactic antibiotics during MIB, open cavity implantation, and V₁₀₀ ≥ 190 cc. No grade ≥ 3 late complications (CTCVE version 4.0) were observed.

Conclusions:
Adjuvant APBI using MIB is associated with favorable long-term oncological outcomes in Japanese patients for low-risk, intermediate-risk, and acceptable groups of patients.

keywords:

HDR-brachytherapy for accelerated partial breast irradiation: Long-term experience from a Japanese institution

APBI, breast conserving surgery, wound complication