Immunoexpression of Bmi-1, CK15, Bcl-2 in different types
of basal cell carcinomas

Aleksandra Iljin; Olga Stasikowska-Kanicka; Tomasz Zieliński; Anna Bąkiewicz; Stanisław Sporny; Ewa Woźniak-Roszkowska; Bogusław Antoszewski

doi:10.5114/ada.2022.120888

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Original paper

Immunoexpression of Bmi-1, CK15, Bcl-2 in different types of basal cell carcinomas

Aleksandra Iljin

¹

,

Olga Stasikowska-Kanicka

²

,

Tomasz Zieliński

¹

,

Anna Bąkiewicz

³

,

Stanisław Sporny

⁴

,

Ewa Woźniak-Roszkowska

⁵

,

Bogusław Antoszewski

¹

Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Lodz, Lodz, Poland
Department of Diagnostic Techniques in Pathomorphology, Medical University of Lodz, Lodz, Poland
Department of Pathology, Medical University of Lodz, Lodz, Poland
Department of Pathomorphology, Andrzej Frycz Modrzewski Krakow University, Krakow, Poland
Department of Plastic Surgery, Prof. Orłowski Memorial Hospital, Centre of Postgraduate Medical Education, Warsaw, Poland

Adv Dermatol Allergol 2022; XXXIX (5): 980-985

DOI: https://doi.org/10.5114/ada.2022.120888

Online publish date: 2022/11/09

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AMA

Iljin A, Stasikowska-Kanicka O, Zieliński T, et al. Immunoexpression of Bmi-1, CK15, Bcl-2 in different types
of basal cell carcinomas. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2022;39(5):980-985. doi:10.5114/ada.2022.120888.

APA

Iljin, A., Stasikowska-Kanicka, O., Zieliński, T., Bąkiewicz, A., Sporny, S.,  & Woźniak-Roszkowska, E. et al. (2022). Immunoexpression of Bmi-1, CK15, Bcl-2 in different types
of basal cell carcinomas. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 39(5), 980-985. https://doi.org/10.5114/ada.2022.120888

Chicago

Iljin, Aleksandra, Olga Stasikowska-Kanicka, Tomasz Zieliński, Anna Bąkiewicz, Stanisław Sporny, Ewa Woźniak-Roszkowska,  and Bogusław Antoszewski. 2022. "Immunoexpression of Bmi-1, CK15, Bcl-2 in different types
of basal cell carcinomas". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 39 (5): 980-985. doi:10.5114/ada.2022.120888.

Harvard

Iljin, A., Stasikowska-Kanicka, O., Zieliński, T., Bąkiewicz, A., Sporny, S., Woźniak-Roszkowska, E.,  and Antoszewski, B. (2022). Immunoexpression of Bmi-1, CK15, Bcl-2 in different types
of basal cell carcinomas. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 39(5), pp.980-985. https://doi.org/10.5114/ada.2022.120888

MLA

Iljin, Aleksandra et al. "Immunoexpression of Bmi-1, CK15, Bcl-2 in different types
of basal cell carcinomas." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 39, no. 5, 2022, pp. 980-985. doi:10.5114/ada.2022.120888.

Vancouver

Iljin A, Stasikowska-Kanicka O, Zieliński T, Bąkiewicz A, Sporny S, Woźniak-Roszkowska E et al. Immunoexpression of Bmi-1, CK15, Bcl-2 in different types
of basal cell carcinomas. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2022;39(5):980-985. doi:10.5114/ada.2022.120888.

Introduction
Basal cell carcinoma (BCC) occurs in aggressive and non-aggressive forms. The expression of immunohistochemical markers varies in different types of BCC.

Aim
Immunohistochemical analysis of selected proteins in BCCs.

Material and methods
The immunohistochemical method was used to examine the immunoexpression of Bmi-1, CK15 and Bcl-2 in 56 cases of BCC divided into four groups. Results: Positive Bmi-1 staining 3–4+ level (nodular type) was seen in 91.3% of samples, 4+ (infiltrative) in 92.3%, 4+ (nodular/infiltrative) – 69.2%, 3+ – 30.8%, in BSC 3+ – 42.8%, and 28.6% each for 2+ and 4+. Low grade positivity (0–1+) in CK15 staining was present in 52.1% of nodular BCC, 46.2% – nodular/infiltrative, 92.3% – infiltrative, and 100% – BSC, but levels 2–3+ in nodular BCC in 47.8%, nodular/infiltrative BCC – 53.8%, infiltrative – 7.7%. Bcl-2 positivity (3–4+) was revealed in nodular BCC in 95.6%, (1–2+) in 100% of BSC, infiltrative and infiltrative/nodular BCC, but the lowest (0–1+) in 76.9% of nodular/infiltrative BCC, 71.4% of BSC, and in 38.4% of infiltrative BCC.

Conclusions
Positive Bmi-1 staining was the highest in the aggressive infiltrative subtype of BCCs, whereas the lowest in basosquamous cell carcinomas (BSC). Infiltrative BCC was characterized by a lower level of CK15 expression than nodular BCC and nodular/infiltrative BCC. Differentiation of Bcl-2 expression depended on the type of tumour; the highest level was found in nodular BCC, low grade in nodular/infiltrative and infiltrative BCCs, and BSC.

keywords:

Immunoexpression of Bmi-1, CK15, Bcl-2 in different types of basal cell carcinomas

Aleksandra Iljin 1 , Olga Stasikowska-Kanicka 2 , Tomasz Zieliński 1 , Anna Bąkiewicz 3 , Stanisław Sporny 4 , Ewa Woźniak-Roszkowska 5 , Bogusław Antoszewski 1

basal cell carcinoma, immunohistochemical markers expression

Aleksandra Iljin

¹

,

Olga Stasikowska-Kanicka

²

,

Tomasz Zieliński

¹

,

Anna Bąkiewicz

³

,

Stanisław Sporny

⁴

,

Ewa Woźniak-Roszkowska

⁵

,

Bogusław Antoszewski

¹