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2/2021
vol. 53
abstract:
Special paper
Invitation to participate in a multi-center study for validation of cerebral computed tomography angiography and computed tomography perfusion in the determination of cerebral circulatory arrest during brain death/death by neurological criteria diagnosis procedure in paediatric population below 12 years of age
Joanna Sołek-Pastuszka
1
,
Katarzyna Chamier-Ciemińska
4
,
Katarzyna Sierakowska
12
,
Alicja Bartkowska-Śniatkowska
15
,
Katarzyna Jończyk-Potoczna
16
,
Elżbieta Byrska-Maciejasz
17
,
Izabela Pągowska-Klimek
24
,
Elżbieta Milewicz-Podgórska
28
,
Monika Bekiesinska-Figatowska
29
,
- Department of Anesthesiology and Intensive Therapy, Pomeranian Medical University, Szczecin, Poland
- Pediatric and Neonatal Intensive Care Unit, University Hospital in Opole, Institute of Medical Science, University of Opole, Poland
- Department of Diagnostic Imaging, University Hospital in Opole, Institute of Medical Science, University of Opole, Poland
- Department of Diagnostic Imaging and Interventional Radiology, Pomeranian Medical University, Szczecin, Poland
- Department of Anesthesiology and Intensive Care, University of Lublin, Poland
- Clinic of Anaesthesiology and Paediatric Intensive Care, Medical University of Lublin, Poland
- Department of Paediatric Radiology, Medical University of Lublin, Poland
- Department of Neurology, Medical University of Lublin, Poland
- 8Department of Neurology, Medical University of Lublin, Poland
- Department of Anesthesiology and Intensive Therapy, Wroclaw Medical University, Poland
- Department of General Radiology, Interventional Radiology and Neuroradiology, Wroclaw Medical University, Poland
- Department of Anesthesiology and Intensive Therapy, Medical University in Bydgoszcz, Poland
- Clinical Unit of Paediatric Anaesthesiology and Intensive Therapy, Antoni Jurasz University Hospital No. 1 in Bydgoszcz, Poland
- Department of Radiology and Diagnostic Imaging, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, Poland
- Department of Pediatric Anesthesiology and Intensive Therapy, Poznan University of Medical Sciences, Poznan, Poland
- Department of Pediatric Radiology, Poznan University of Medical Sciences, Poznan, Poland
- Department of Pediatric Anesthesiology and Intensive Care, University Children’s Hospital, Krakow, Poland
- Department of Radiology, University Children’s Hospital, Krakow, Poland
- Department of Anesthesia and Intensive Care, The Children’s Memorial Health Institute, Warsaw, Poland
- Department of Diagnostic Imaging, The Children’s Memorial Health Institute, Warsaw, Poland
- The Children’s Memorial Health Institute, Warsaw, Poland
- Department of Anaesthesiology and Intensive Care with Postoperative Subunit, Pediatric University Hospital in Bialystok, Poland
- Department of Paediatric Radiology, Medical University of Bialystok, Poland
- Department of Pediatric Anaesthesiology and Intensive Therapy, Paediatric University Hospital, Warsaw, Poland
- Department of Paediatric Radiology, Medical University in Warsaw, Poland
- Department of Pediatric Anesthesiology and Intensive Therapy, Independent Public Pediatric Hospital in Warsaw, Poland
- Department of Intensive Therapy and Anesthesiology, Regional Specialized Children’s Hospital in Olsztyn, Poland
- Department of Radiology, Regional Specialized Children’s Hospital in Olsztyn, Poland
- Department of Diagnostic Imaging, Institute of Mother and Child, Warsaw, Poland
- 2nd Department of Radiology, Medical University of Gdansk, Poland
- Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Medical University of Gdansk, Poland
- Department of Anaesthesiology and Intensive Therapy, Poznan University of Medical Sciences, Poznan, Poland
Anaesthesiol Intensive Ther 2021; 53, 2: 97–102
Online publish date: 2021/06/21
PlumX metrics:
In recent years commensal microorganisms are not just “passive occupants”, but important element of homeostasis. There are numerous reports documenting the composition and role of the gut, skin or vagina microbiome but the role of commensal organisms living in the lungs is relatively unknown. Pulmonary microbiome impact on the immune response of the host organism and may indicate new therapeutic directions. Lung microbiome, by modulating the expression of innate immunity genes, causes an increase in the concentration of IL-5, IL-10, IFNγ and CCL11, affects the TLR4 dependent response of pulmonary macrophages and modulate the production of antibacterial peptides contained in the mucus. It is documented that disorders of the lung microbiome contribute to asthma or chronic obstructive pulmonary disease. However it is known that pulmonary dysbiosis also occurs in critically ill patients. It is possible, therefore, that microbiota-targeted therapy may constitute the future therapeutic direction in ICU.
keywords:
ICU, lung microbiom, lung-gut interaction
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