ISSN: 1734-1922
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1/2009
 
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abstract:

Invited review
Intracytoplasmic sperm injection: current perspectives and future development

Alex C. Varghese
,
Amir Arsalan
,
Ashok Agarwal

Arch Med Sci 2009; 5, 1A: S109–S114
Online publish date: 2009/06/10
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Intracytoplasmic sperm injection (ICSI), a novel technique rapidly gaining popularity among infertile couples, alleviates the burdens posed by male factor infertility by offering infertile couples a chance to conceive. Although numerous studies suggest success rates comparable to traditional in vitro fertilization, ICSI is not without fault. Potential associated risks include, but certainly are not limited to, birth defects, DNA fragmentation, de novo Y-chromosome microdeletions, paternal mtDNA disease transmission, chromosomal aberrations, and genomic imprinting disorders. Fortunately, there has been ongoing research to develop a more effective ICSI protocol. This paper explores potential risks associated with prenatal and postnatal development in ICSI offspring, as well as modern technical advances in the ICSI protocol.
keywords:

intracytoplasmic sperm injection, sperm selection, male infertility
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