ISSN: 1734-1922
Archives of Medical Science Special Issues
Current issue Archive Archives of Medical Science
Search
3/2007
 
Share:
Send email
Share:
abstract:

Invited review
Trimetazidine and liver preservation against ischaemia-reperfusion injury

Ismail B. Mosbah
,
Hassen B. Abdennebi
,
Mohamed A. Zaouali
,
Susagna Padrissa-Altes
,
Carmen Peralta
,
Joan Roselló-Catafau

Arch Med Sci 2007; 3, 3A: S59-S61
Online publish date: 2008/01/10
View full text Get citation
 
Trimetazidine is an anti-ischaemic drug used for angina pectoris treatment. Recently, it has been shown that trimetazidine protects against hepatic ischaemia reperfusion injury. Several hypotheses have been proposed to explain the exact hepatoprotective mechanisms but they still remain unclear. This review assesses the possible mechanisms responsible for the increase of the liver’s tolerance against ischaemia-reperfusion injury with special emphasis on: (1) the prevention of oxidative stress and protection of mitochondrial function; (2) the generation of vasoactive mediators such as nitric oxide and endothelins; and finally (3) the preservation of liver energy metabolism.
keywords:

ischaemia-reperfusion injury, liver, trimetazidine
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2024 Termedia Sp. z o.o.
Developed by Bentus.