eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications
1/2020
vol. 37
 
Share:
Send email
Share:
abstract:
Original paper

Nineteen-year retrospective evaluation of pemphigus in a single dermatology centre in Istanbul, Turkey

Mukaddes Kavala
1
,
İlkin Zindancı
2
,
Zafer Turkoglu
3
,
Burce Can Kuru
2
,
Emin Ozlu
4
,
Mehmet Simsek
2

  1. Departments of Dermatology, Kafkas University, Kars, Turkey
  2. Departments of Dermatology, Istanbul Medeniyet University, Istanbul, Turkey
  3. Department of Dermatology, Haseki Training and Research Hospital, Istanbul, Turkey
  4. Departments of Dermatology, Duzce University, Duzce, Turkey
Adv Dermatol Allergol 2020; XXXVII (1): 23-28
DOI: https://doi.org/10.5114/ada.2020.93380
Online publish date: 2020/03/09
View full text Get citation
 
Introduction
Pemphigus is an autoimmune intra-epidermal bullous disease of the skin and mucosae.

Aim
To retrospectively evaluate the course, prognosis and clinical features of pemphigus.

Material and methods
The files of 196 pemphigus patients admitted to our clinic between December 1995 and December 2014 were collected and analysed.

Results
The male to female ratio among patients was 1 : 1.88. Pemphigus vulgaris (PV) was the most common clinical variant observed in 175 (89.3%) of the patients, followed by pemphigus foliaceus (PF) in 14 (7.1%) of the patients. The mean patient age at disease onset was 50 years. PV presented itself as skin lesions in 55 (31.4%) of the patients and as oral mucosa lesions in 120 (68.6%) of the patients. Complete remission and treatment withdrawal were obtained in 112 (57.1%) of the patients, for a mean period of 2.91 ±2.66 years (range: 4 months to 13 years). The mortality rate was 6%, and relapse occurred in 16 (14.3%) of the patients for a mean relapse period of 2.15 ±1.88 years (range: 6 months to 7 years). Mucocutaneous pemphigus (MCP) was the major clinical pattern observed in 96 (49%) of the patients.

Conclusions
Within our study population, pemphigus predominately affected females, and the most common clinical variant was PV, a subtype that frequently occurs in middle-aged individuals. MCP was the most common clinical pattern. Although MCP and higher doses of corticosteroids were needed to control pemphigus, they did not seem to influence the prognosis.

keywords:

pemphigus, treatment, mortality
FEATURED PRODUCTS
BOOKS
• Atopowe Zapalenie Skóry • Choroby alergiczne w praktyce lekarza rodzinnego • Alergologia – kompendium
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2024 Termedia Sp. z o.o.
Developed by Bentus.