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eISSN: 2719-3209
ISSN: 0023-2157
Klinika Oczna / Acta Ophthalmologica Polonica
Bieżący numer Archiwum Filmy Artykuły w druku O czasopiśmie Suplementy Rada naukowa Recenzenci Bazy indeksacyjne Prenumerata Kontakt Zasady publikacji prac Opłaty publikacyjne Standardy etyczne i procedury
Panel Redakcyjny
Zgłaszanie i recenzowanie prac online
SCImago Journal & Country Rank
4/2009
vol. 111
 
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Artykuł oryginalny

Ocena stężenia VEGF i IGF-1 we krwi obwodowej wcześniaków – próba korelacji z rozwojem retinopatii wcześniaczej, implikacje kliniczne

Anna Machalińska
1, 2
,
Monika Modrzejewska
3
,
Violetta Dziedziejko
2
,
Maciej Kotowski
2
,
Krzysztof Safranow
2
,
Aleksandra Herbowska
2
,
Danuta Karczewicz
3

  1. Katedra i Zakład Histologii i Embriologii Pomorskiej Akademii Medycznej w Szczecinie
  2. Katedra Fizjopatologii i Zakładu Patologii Ogólnej Pomorskiej Akademii Medycznej w Szczecinie
  3. Katedra i Klinika Okulistyki Pomorskiej Akademii Medycznej w Szczecinie
Klinika Oczna 2009, 111 (4): 302-306
Data publikacji online: 2009/12/19
Pełna treść artykułu Pobierz cytowanie
 


Introduction
Purpose: Insulin-like growth factor-1 plays an important role in fetal growth and development, and its level increases with gestational age. The latest reports show that IGF-1 can directly influence the production of VEGF and regulate the development of blood vessels. Thus, the aim of the study was to evaluate the plasma concentrations of IGF-1 and VEGF as well as analyze their mutual correlation in preterm infants with retinopathy of prematurity (ROP), compared with preterm infants without ROP and full-term babies.

Material and methods
To address this issue, peripheral blood samples (PB) were analyzed and collected 10 weeks after delivery from: 25 preterm infants with proliferative stage of retinopathy of prematurity (ROP) and neovascularization (stage 3 or more advanced), 25 preterm infants without ROP, and 25 healthy full-term control infants. Plasma concentrations of VEGF and IGF-1 were measured using high-sensitivity enzyme-linked immunosorbent assay (ELISA) kits.

Results
Increased concentrations of VEGF (p<0.05), were found in the PB of the preterm infants with ROP compared with the preterm babies without retinopathy as well as with the full-term control infants, in whom the lowest levels of the growth factor were observed. The plasma concentrations of IGF-1 in the preterm infants were significantly lower than those of the full-term babies (p<0.001). After adjustment for gestational age as a independent variable, a tendency to higher concentrations of IGF-1 was observed in the preterm infants with ROP.

Conclusions
Disturbances in the interactions of VEGF and IGF-1 at early stages of ROP, leading to uncontrolled increases in their levels in the proliferative phase of disease, can play an important role in the pathogenesis of retinopathy of prematurity.

słowa kluczowe:

VEGF, IGF-1, retinopatia wcześniacza, neowaskularyzacja siatkówkowa

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