Original paper<br>Cutaneous drug reactions in children: a multicentric study

Nursel Dilek; Hatice Uce Özkol; Ayse Akbaş; Fadime Kılınç; Aziz Ramazan Dilek; Yunus Saral; Ahmet Metin; Ömer Çalka

doi:10.5114/pdia.2014.43881

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

6/2014
vol. 31

Send email

Copy url:

abstract:

Original paper
Cutaneous drug reactions in children: a multicentric study

Nursel Dilek

,

Hatice Uce Özkol

,

Ayse Akbaş

,

Fadime Kılınç

,

Aziz Ramazan Dilek

,

Yunus Saral

,

Ahmet Metin

,

Ömer Çalka

Postep Derm Alergol 2014; XXXI, 6: 368–371

DOI: https://doi.org/10.5114/pdia.2014.43881

Online publish date: 2014/12/03

View full text Get citation

Introduction: According to studies conducted in outpatients, it is estimated that 2.5% of children who are treated with a drug will experience a cutaneous adverse drug reaction (CADR).

Aim: To analyze the CADR reports involving pediatric patients recorded by three different university hospitals for describing common, serious, and interesting cutaneous drug eruption patterns.

Material and methods: For this purpose, the patients’ data from three different universities were reviewed retrospectively. Diagnosis was based on history, clinical findings and laboratory test results. The CADRs were classified into seven categories; urticaria, angioedema, maculopapular eruption, fixed drug eruption, erythema multiforme, acute generalized exanthematous pustulosis, drug rash with eosinophilia and systemic symptoms syndrome.

Results: A total of 122 patients who had CADRs were enrolled in the study. The most frequently detected cutaneous drug reactions were urticaria + angioedema. Most of patients had no previous experience with the same drug and the most common causative agent of CADRs was antimicrobials.

Conclusions: Since CADRs are relatively rare, the current multicentric study can provide meaningful information about the cutaneous eruption patterns of commonly used drugs.

keywords:

Original paperCutaneous drug reactions in children: a multicentric study

Nursel Dilek , Hatice Uce Özkol , Ayse Akbaş , Fadime Kılınç , Aziz Ramazan Dilek , Yunus Saral , Ahmet Metin , Ömer Çalka

drug, allergy, cutaneous, children

Original paper
Cutaneous drug reactions in children: a multicentric study

Nursel Dilek

,

Hatice Uce Özkol

,

Ayse Akbaş

,

Fadime Kılınç

,

Aziz Ramazan Dilek

,

Yunus Saral

,

Ahmet Metin

,

Ömer Çalka