eISSN: 2081-2841
ISSN: 1689-832X
Journal of Contemporary Brachytherapy
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4/2014
vol. 6
 
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abstract:

Original paper
Depth determination of skin cancers treated with superficial brachytherapy: ultrasound vs. histopathology

Rosa Ballester-Sánchez
,
Olga Pons-Llanas
,
Margarita Llavador-Ros
,
Rafael Botella-Estrada
,
Antonio Ballester-Cuńat
,
Alejandro Tormo-Micó
,
Francisco Javier Celadá-Álvarez
,
Silvia Rodríguez-Villalba
,
Manuel Santos-Ortega
,
Facundo Ballester-Pallarés
,
Jose Perez-Calatayud

J Contemp Brachytherapy 2014; 6, 4: 356–361
DOI: https://doi.org/10.5114/jcb.2014.47860
Online publish date: 2014/12/31
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Purpose: The purpose of this study is to compare high frequency ultrasonography (HFUS) and histpathologic assessment done by punch biopsy in order to determine depth of basal cell carcinoma (BCC), in both superficial and nodular BCCs prior to brachytherapy treatment.

Material and methods: This study includes 20 patients with 10 superficial and 10 nodular BCCs. First, punch biopsy was done to confirm the diagnosis and to measure tumour depth (Breslow rate). Subsequently, HFUS was done to measure tumour depth to search for correlation of these two techniques.

Results: Neither clear tendency nor significance of the punch biopsy vs. HFUS depth determination is observed. Depth value differences with both modalities resulted patient dependent and then consequence of its uncertainty. Conceptually, HFUS should determine the macroscopic lesion (gross tumour volume – GTV), while punch biopsy is able to detect the microscopic extension (clinical target volume – CTV). Uncertainties of HFUS are difficult to address, while punch biopsy is done just on a small lesion section, not necessarily the deepest one.

Conclusions: According to the results, HFUS is less accurate at very shallow depths. Nodular cases present higher depth determination differences than superficial ones. In our clinical practice, we decided to prescribe at 3 mm depth when HFUS measurements give depth lesion values smaller than this value.
keywords:

basal cell carcinoma, electronic brachytherapy, punch biopsy, skin brachytherapy, skin cancer, ultrasound

  
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