eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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4/2013
vol. 30
 
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abstract:

Original paper
Genetic polymorphisms of CYP2D6 oxidation in patients with autoimmune bullous diseases

Mariola Rychlik-Sych
,
Małgorzata Baranska
,
Elzbieta Waszczykowska
,
Jolanta Dorota Torzecka
,
Agnieszka Zebrowska
,
Jadwiga Skretkowicz

Postep Derm Alergol 2013; XXX, 4: 211–217
DOI: https://doi.org/10.5114/pdia.2013.37030
Online publish date: 2013/08/27
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Introduction: Bullous skin diseases, which include, among others pemphigoid, pemphigus, and dermatitis herpetiformis are classified as severe autoimmune dermatoses. It has been shown that a pattern of xenobiotic metabolism may play a role in the pathogenesis of autoimmune diseases.

Aim: To estimate whether the CYP2D6 genotype may be considered a predisposing factor in autoimmune bullous diseases induction.

Material and methods: The study included 72 patients with autoimmune bullous diseases: 37 with pemphigoid,

21 with pemphigus, and 14 with dermatitis herpetiformis (DH). The CYP2D6 genotypes were analyzed by the polymerase chain reaction fragment length polymorphism (PCR-RFLP) method.

Results: Relative risk of DH development for particular genotype carriers expressed by odds ratio (OR) was statistically significantly higher for subjects with CYP2D6*1/CYP2D6*4 (OR = 4.2; p = 0.0104) and 2-fold higher for subjects with CYP2D6*4 (OR = 2.3; p = 0.0351).

Conclusions: The results of the present study show that the CYP2D6 oxidation polymorphism cannot be considered a risk factor for development of pemphigoid and pemphigus, however it might have an impact on dermatitis herpetiformis.
keywords:

genetic polymorphism, CYP2D6, pemphigoid, pemphigus, dermatitis herpetiformis
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