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ISSN: 1689-832X
Journal of Contemporary Brachytherapy
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1/2013
vol. 5
 
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abstract:

Original paper
Image-guided brachytherapy (IGBT) combined with whole pelvic intensity-modulated radiotherapy (WP-IMRT) for locally advanced cervical cancer: a prospective study from Chiang Mai University Hospital, Thailand

Ekkasit Tharavichitkul
,
Somsak Wanwilairat
,
Somvilai Chakrabandhu
,
Pitchayaponne Klunklin
,
Wimrak Onchan
,
Damrongsak Tippanya
,
Wannapa Nopnop
,
Razvan Galalae
,
Imjai Chitapanarux

J Contemp Brachytherapy 2013; 5, 1: 10–16
DOI: https://doi.org/10.5114/jcb.2013.34338
Online publish date: 2013/03/31
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Purposes: A report of preliminary results and toxicity profiles using image-guided brachytherapy (IGBT) combined with whole pelvic intensity-modulated radiation therapy (WP-IMRT) for locally advanced cervical cancer.

Material and methods: Fifteen patients with locally advanced cervical cancer were enrolled into the study. WP-IMRT was used to treat the Clinical Target Volume (CTV) with a dose of 45 Gy in 25 fractions. Concurrent cisplatin (40 mg/m2) was prescribed during radiotherapy (RT) on weekly basis. IGBT using computed tomography was performed at the dose of 7 Gy × 4 fractions to the High-Risk Clinical Target Volume (HR-CTV).

Results: The mean cumulative doses – in terms of equivalent dose of 2 Gy (EQD2) – of IGBT plus WP-IMRT to

HR-CTV, bladder, rectum, and sigmoid colon were 88.3, 85.0, 68.2 and 73.6 Gy, respectively. In comparison with standard (point A prescription) dose-volume histograms, volume-based image-guided brachytherapy improved the cumulative doses for bladder of 67%, rectum of 47% and sigmoid of 46%. At the median follow-up time of 14 months, the local control, metastasis-free survival and overall survival rates were 93%, 100% and 93%, respectively. No grade 3-4 acute and late toxicities were observed.

Conclusion: The combination of image-guided brachytherapy and intensity-modulated radiotherapy improved the dose distribution to tumor volumes and avoided overdose in OARs which could be converted in excellent local control and toxicity profiles.
keywords:

brachytherapy, cervical cancer, IGBT, IMRT

  
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