Original paper<br>The role of selectins in alopecia areata

Wiesława Sudnik; Aleksandra Dańczak-Pazdrowska; Wojciech Silny; Agnieszka Osmola-Mańkowska; Jakub Pazdrowski; Adriana Polańska

doi:10.5114/pdia.2014.40946

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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1/2015
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abstract:

Original paper
The role of selectins in alopecia areata

Wiesława Sudnik

,

Aleksandra Dańczak-Pazdrowska

,

Wojciech Silny

,

Agnieszka Osmola-Mańkowska

,

Jakub Pazdrowski

,

Adriana Polańska

Postep Derm Alergol 2015; XXXII, 1: 27–32

DOI: https://doi.org/10.5114/pdia.2014.40946

Online publish date: 2015/02/03

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Introduction: One of the main histopathological features of alopecia areata (AA) is a lymphocytic infiltration that surrounds hair follicles. Soluble forms of E, L, P-selectins are known indicators of ongoing inflammation. There are no studies regarding the assessment of their contribution in AA.

Aim: To assess serum concentrations of selectins (E-selectin, L-selectin and P-selectin) in patients with AA in relation to selected clinical parameters, including disease severity and activity.

Material and methods: Sixty-four patients with AA were involved in the study. The diagnosis was based on physical examination and photodermoscopy. The control group consisted of 40 healthy subjects. The serum concentrations of soluble E-selectin, L-selectin and P-selectin were detected with ELISA method.

Results: Statistically significantly higher levels of E, P, L-selectins were found in AA patients as compared with the healthy group. Serum concentrations of soluble forms of E- and L-selectins correlated with the severity of the disease, while E-selectin with activity of AA.

Conclusions: This study shows that selectins may play an important role in the pathogenesis of AA and may be a target of future therapies in this disease.

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Original paperThe role of selectins in alopecia areata

Wiesława Sudnik , Aleksandra Dańczak-Pazdrowska , Wojciech Silny , Agnieszka Osmola-Mańkowska , Jakub Pazdrowski , Adriana Polańska

alopecia areata, E-selectin, P-selectin, L-selectin

Original paper
The role of selectins in alopecia areata

Wiesława Sudnik

,

Aleksandra Dańczak-Pazdrowska

,

Wojciech Silny

,

Agnieszka Osmola-Mańkowska

,

Jakub Pazdrowski

,

Adriana Polańska