eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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6/2013
vol. 30
 
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abstract:

Original paper
Transforming growth factor-β1 in plaque morphea

Aleksandra Dańczak-Pazdrowska
,
Michał J. Kowalczyk
,
Beata Szramka-Pawlak
,
Justyna Gornowicz-Porowska
,
Aleksandra Szewczyk
,
Wojciech Silny
,
Marta Molińska-Glura
,
Anna Olewicz-Gawlik
,
Ryszard Żaba
,
Jakub Pazdrowski
,
Paweł Hrycaj

Postep Derm Alergol 2013; XXX, 6: 337–342
DOI: https://doi.org/10.5114/pdia.2013.39431
Online publish date: 2013/12/18
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Introduction: Morphea (localized scleroderma) is a rare cutaneous disease characterized by skin fibrosis of unknown pathogenesis. Transforming growth factor-β (TGF-β) is a potent profibrotic factor. The role of TGF-β in morphea remains unclear.

Aim: The goal of this study was to estimate the expression level of TGF-β1 in skin and peripheral blood mononuclear cells as well as the plasma levels of TGF-β1 in plaque morphea (MEP).

Material and methods: The study involved 20 MEP patients. Three control groups were involved: 1 – plasma: 36 healthy volunteers; 2 – PBMC: 47 healthy volunteers; 3 – skin biopsies: 13 samples collected during mastectomy (breast cancer was not skin involved). The analysis of TGF-β1 plasma levels was performed with the use an adequate ELISA kit, while real-time polymerase chain reaction was employed for the expression of TGF-β1 in peripheral blood mononuclear cells (PBMC) and skin.

Results: In our study we have not detected differences in TGF-β 1 expression in PBMC, skin, nor in plasma levels of TGF-β1 between MEP patients and healthy controls, regardless of disease activity and its duration.

Conclusions:: The results of our study contradict the claim of the substantial role of TGF-β1 in the most common morphea subtype – MEP.
keywords:

morphea, scleroderma, transforming growth factor-β, transforming growth factor
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