Original paper<br>
Estimation of vancomycin MIC for Staphylococcus aureus in patients treated in the Chair and Department of Dermatology, Poznan University of Medical Sciences

Hanna Tomczak; Aleksandra Dańczak-Pazdrowska; Anna Horla; Monika Duś-Żuchowska; Wioleta Błażejewska; Adriana Polańska; Dominika Okrutnik

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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6/2011
vol. 28

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abstract:

Original paper
Estimation of vancomycin MIC for Staphylococcus aureus in patients treated in the Chair and Department of Dermatology, Poznan University of Medical Sciences

Hanna Tomczak

,

Aleksandra Dańczak-Pazdrowska

,

Anna Horla

,

Monika Duś-Żuchowska

,

Wioleta Błażejewska

,

Adriana Polańska

,

Dominika Okrutnik

Post Dermatol Alergol 2011; XXVIII, 6: 462–466

Online publish date: 2011/12/28

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AMA

Tomczak H, Dańczak-Pazdrowska A, Horla A, et al. Original paper
Estimation of vancomycin MIC for Staphylococcus aureus in patients treated in the Chair and Department of Dermatology, Poznan University of Medical Sciences. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2011;28(6):462-466.

APA

Tomczak, H., Dańczak-Pazdrowska, A., Horla, A., Duś-Żuchowska, M., Błażejewska, W.,  & Polańska, A. et al. (2011). Original paper
Estimation of vancomycin MIC for Staphylococcus aureus in patients treated in the Chair and Department of Dermatology, Poznan University of Medical Sciences. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 28(6), 462-466.

Chicago

Tomczak, Hanna, Aleksandra Dańczak-Pazdrowska, Anna Horla, Monika Duś-Żuchowska, Wioleta Błażejewska, Adriana Polańska,  and Dominika Okrutnik. 2011. "Original paper
Estimation of vancomycin MIC for Staphylococcus aureus in patients treated in the Chair and Department of Dermatology, Poznan University of Medical Sciences". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 28 (6): 462-466.

Harvard

Tomczak, H., Dańczak-Pazdrowska, A., Horla, A., Duś-Żuchowska, M., Błażejewska, W., Polańska, A.,  and Okrutnik, D. (2011). Original paper
Estimation of vancomycin MIC for Staphylococcus aureus in patients treated in the Chair and Department of Dermatology, Poznan University of Medical Sciences. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 28(6), pp.462-466.

MLA

Tomczak, Hanna et al. "Original paper
Estimation of vancomycin MIC for Staphylococcus aureus in patients treated in the Chair and Department of Dermatology, Poznan University of Medical Sciences." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 28, no. 6, 2011, pp. 462-466.

Vancouver

Tomczak H, Dańczak-Pazdrowska A, Horla A, Duś-Żuchowska M, Błażejewska W, Polańska A et al. Original paper
Estimation of vancomycin MIC for Staphylococcus aureus in patients treated in the Chair and Department of Dermatology, Poznan University of Medical Sciences. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2011;28(6):462-466.

Introduction : Staphylococcus aureus (S. aureus ) represents a significant aetiological factor in infections of skin and soft tissues. Resistance to vancomycin is very rare. In recent years the MIC creep phenomenon has been noted. At present, it is suggested that S. aureus strains with vancomycin minimal inhibitory concentration (MIC) at a level > 1 µg/ml poorly respond to treatment.

Aim : The study was aimed to compare MIC evaluated in the automatic system of Vitek with the real MIC of vancomycin for S. aureus strains isolated from patients treated in the Department of Dermatology, Poznan University of Medical Sciences.

Material and methods : Material for the studies involved 80 smears sampled from dermal lesions in patients diagnosed and treated in the Department of Dermatology, Poznan University of Medical Sciences in Poznan between May 2008 and December 2010.

Results : Methicillin-sensitive S. aureus strains (MSSA) were isolated in 76 cases (95%), while methicillin-resistant S. aureus (MRSA) – in 4 cases (5%). Using the automatic Vitek technique in 72 cases (90%), the obtained vancomycin MIC for S. aureus amounted to ≤ 0.5 µg/ml, in 5 cases to 1 µg/ml and in 3 cases to 2 µg/ml. Using Etest technique, the real MIC amounted in one case to 0.5 µg/ml, in 1 case to 0.75 µg/ml, in 1 case to 1 µg/ml, in 19 cases to 1.5 µg/ml and in 58 cases to 2.0 µg/ml.

Conclusions : Due to the MIC creep phenomenon and extensive diversities obtained in estimates of S. aureus resistance to vancomycin, the authors suggest estimating the real MIC.

keywords:

Original paper Estimation of vancomycin MIC for Staphylococcus aureus in patients treated in the Chair and Department of Dermatology, Poznan University of Medical Sciences

Hanna Tomczak , Aleksandra Dańczak-Pazdrowska , Anna Horla , Monika Duś-Żuchowska , Wioleta Błażejewska , Adriana Polańska , Dominika Okrutnik

infections of skin, Staphylococcus aureus, vancomycin

Original paper
Estimation of vancomycin MIC for Staphylococcus aureus in patients treated in the Chair and Department of Dermatology, Poznan University of Medical Sciences

Hanna Tomczak

,

Aleksandra Dańczak-Pazdrowska

,

Anna Horla

,

Monika Duś-Żuchowska

,

Wioleta Błażejewska

,

Adriana Polańska

,

Dominika Okrutnik