P-selectin glycoprotein ligand-1 is diversely expressed in the primary tumour and venous thrombus of clear cell renal cancer and correlates with poor overall survival

Rafał Pęksa; Sumit Sharma; Michał Kunc; Marta Popęda; Le Qu; Mikołaj Frankiewicz; Marcin Folwarski; Piotr Radziszewski; Łukasz Zapała

doi:10.5114/wo.2024.144225

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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3/2024
vol. 28

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abstract:

Original paper

P-selectin glycoprotein ligand-1 is diversely expressed in the primary tumour and venous thrombus of clear cell renal cancer and correlates with poor overall survival

Rafał Pęksa

¹

,

Sumit Sharma

²

,

Michał Kunc

¹

,

Marta Popęda

¹

,

Le Qu

^{3, 4}

,

Mikołaj Frankiewicz

⁵

,

Marcin Folwarski

^{6, 7}

,

Piotr Radziszewski

²

,

Łukasz Zapała

²

Department of Pathomorphology, Medical University of Gdańsk, Gdańsk, Poland
Clinic of General, Oncological and Functional Urology, Medical University of Warsaw, Warsaw, Poland
Department of Urology Jinling Hospital Affiliated Hospital of Medical School Nanjing University, Nanjing Jiangsu, China
Department of Urology Jinling Hospital Jinling School of Clinical Medicine Nanjing Medical University, Nanjing Jiangsu, China
Department of Urology, Medical University of Gdańsk, Gdańsk, Poland
Department of Clinical Nutrition and Dietetics, Medical University of Gdańsk, Gdańsk, Poland
Home Enteral and Parenteral Nutrition Unit, General Surgery Department, Nicolaus Copernicus Hospital, Gdańsk, Poland

Contemp Oncol (Pozn) 2024; 28 (3): 253–259

DOI: https://doi.org/10.5114/wo.2024.144225

Online publish date: 2024/10/15

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AMA

Pęksa R, Sharma S, Kunc M, et al. P-selectin glycoprotein ligand-1 is diversely expressed in the primary tumour and venous thrombus of clear cell renal cancer and correlates with poor overall survival. Contemporary Oncology/Współczesna Onkologia. 2024;28(3):253-259. doi:10.5114/wo.2024.144225.

APA

Pęksa, R., Sharma, S., Kunc, M., Popęda, M., Qu, L.,  & Frankiewicz, M. et al. (2024). P-selectin glycoprotein ligand-1 is diversely expressed in the primary tumour and venous thrombus of clear cell renal cancer and correlates with poor overall survival. Contemporary Oncology/Współczesna Onkologia, 28(3), 253-259. https://doi.org/10.5114/wo.2024.144225

Chicago

Pęksa, Rafał, Sumit Sharma, Michał Kunc, Marta Popęda, Le Qu, Mikołaj Frankiewicz,  and Marcin Folwarski et al. 2024. "P-selectin glycoprotein ligand-1 is diversely expressed in the primary tumour and venous thrombus of clear cell renal cancer and correlates with poor overall survival". Contemporary Oncology/Współczesna Onkologia 28 (3): 253-259. doi:10.5114/wo.2024.144225.

Harvard

Pęksa, R., Sharma, S., Kunc, M., Popęda, M., Qu, L., Frankiewicz, M., Folwarski, M., Radziszewski, P.,  and Zapała, Ł. (2024). P-selectin glycoprotein ligand-1 is diversely expressed in the primary tumour and venous thrombus of clear cell renal cancer and correlates with poor overall survival. Contemporary Oncology/Współczesna Onkologia, 28(3), pp.253-259. https://doi.org/10.5114/wo.2024.144225

MLA

Pęksa, Rafał et al. "P-selectin glycoprotein ligand-1 is diversely expressed in the primary tumour and venous thrombus of clear cell renal cancer and correlates with poor overall survival." Contemporary Oncology/Współczesna Onkologia, vol. 28, no. 3, 2024, pp. 253-259. doi:10.5114/wo.2024.144225.

Vancouver

Pęksa R, Sharma S, Kunc M, Popęda M, Qu L, Frankiewicz M et al. P-selectin glycoprotein ligand-1 is diversely expressed in the primary tumour and venous thrombus of clear cell renal cancer and correlates with poor overall survival. Contemporary Oncology/Współczesna Onkologia. 2024;28(3):253-259. doi:10.5114/wo.2024.144225.

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Introduction:
In clear cell renal cell carcinoma (ccRCC), intravascular extension often results in neoplastic thrombus formation, impacting patient outcomes.

Material and methods:
We assessed P-selectin glycoprotein ligand-1 (PSGL-1) expression in the primary tumours and thrombi of 82 ccRCC patients.

Results:
Notably, PSGL-1 expression varied between tumour compartments, with higher prevalence in thrombus tumour cells (TC) and primary tumour-associated immune cells (TAIC). Positive TC PSGL-1 correlated with high-grade histology, while TAIC PSGL-1 was associated with tumour necrosis. Univariate survival analysis identified PSGL-1 positivity in TC of primary tumours and TAIC in thrombi as indicators of poorer overall survival. These findings suggest a potential role for PSGL-1 in the mediation of tumour thrombus formation, highlighting its relevance in biology of ccRCC.

Conclusions:
The increased expression of PSGL-1 in venous thrombi suggests its potential role in facilitating TC interactions with platelets and endothelium, potentially contributing to metastatic spread and worse outcomes. Understanding these expression patterns may aid in the development of novel therapeutic strategies and personalised treatment approaches for ccRCC patients.

keywords:

P-selectin glycoprotein ligand-1 is diversely expressed in the primary tumour and venous thrombus of clear cell renal cancer and correlates with poor overall survival

Rafał Pęksa 1 , Sumit Sharma 2 , Michał Kunc 1 , Marta Popęda 1 , Le Qu 3, 4 , Mikołaj Frankiewicz 5 , Marcin Folwarski 6, 7 , Piotr Radziszewski 2 , Łukasz Zapała 2

renal cell cancer, tumour thrombus, P-selectin glycoprotein ligand-1, biomarker

Rafał Pęksa

¹

,

Sumit Sharma

²

,

Michał Kunc

¹

,

Marta Popęda

¹

,

Le Qu

^{3, 4}

,

Mikołaj Frankiewicz

⁵

,

Marcin Folwarski

^{6, 7}

,

Piotr Radziszewski

²

,

Łukasz Zapała

²