Plasma concentrations of cathelicidin and β-defensins
and their correlations in patients with basal cell carcinoma

Marta Fijałkowska; Marek Kowalski; Bogusław Antoszewski

doi:10.5114/ada.2022.113809

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Letter to the Editor

Plasma concentrations of cathelicidin and β-defensins and their correlations in patients with basal cell carcinoma

Marta Fijałkowska

¹

,

Marek Kowalski

²

,

Bogusław Antoszewski

¹

Department of Plastic, Reconstructive and Aesthetic Surgery, Second Chair of Surgery, Medical University of Lodz, Lodz, Poland
Department of Immunology and Allergy, Medical University of Lodz, Lodz, Poland

Adv Dermatol Allergol 2022; XXXIX (1): 226-227

DOI: https://doi.org/10.5114/ada.2022.113809

Online publish date: 2022/02/28

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Non-melanoma skin cancers (NMSCs) are the most common neoplasms accounting for more than 95% of all of skin tumours and their incidence is dramatically increasing worldwide [1–3]. Skin cancers represent an important health problem and cause economic burden for the society and health services; it is said that NMSCs are about four times more costly than melanoma [4].

The pathogenesis of skin cancers is complex, however its exact mechanism of development has not been clearly described [3, 5]. There are some reports that paid attention to changes in the expression profile of specific proteins linked to skin carcinogenesis [6–9]. In this group there are b-defensins and cathelicidin, which are the key participles of innate host defence against microorganisms [6, 10].

The aim of this paper is to measure the plasma concentrations of b-defensins and cathelicidin in patients with basal cell carcinoma (BCC) in comparison to healthy controls (HC) and to check the significance of their correlations.

Plasma concentrations of cathelicidin and β-defensins and their correlations in patients with basal cell carcinoma

Marta Fijałkowska 1 , Marek Kowalski 2 , Bogusław Antoszewski 1

Marta Fijałkowska

¹

,

Marek Kowalski

²

,

Bogusław Antoszewski

¹