eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
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SCImago Journal & Country Rank
2/2023
vol. 27
 
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abstract:
Original paper

Prognostic value of geriatric nutritional risk index for patients with biliary tract cancer undergoing surgical resection – a single-institution retrospective cohort study

Shinichi Ikuta
1
,
Takayoshi Nakajima
1
,
Masataka Fujikawa
1
,
Tsukasa Aihara
1
,
Naoki Yamanaka
1

  1. Department of Surgery, Meiwa Hospital, Japan
Contemp Oncol (Pozn) 2023; 27 (2): 65–70
Online publish date: 2023/05/22
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Introduction:
The geriatric nutritional risk index (GNRI) is an index of nutritional status associated with clinical outcomes in various cancers; however, its prognostic value in biliary tract cancer (BTC) remains to be elucidated. This retrospective study aimed to investigate the association between preoperative GNRI and long-term prognosis of patients with BTC undergoing surgical resection.

Material and methods:
A total of 213 patients were included. The relationships between GNRI and clinicopathological variables, including inflammatory markers such as C-reactive protein (CRP) and neutrophil-to-lympho­cyte ratio, were analysed. The impact of GNRI on overall survival (OS) and relapse-free survival (RFS) was investigated by Kaplan-Meier curves and Cox proportional hazards models.

Results:
Applying a GNRI cut-off of 98, the low-GNRI group comprised 135 patients (63%). The low-GNRI group had elevated carbohydrate antigen 19-9 and CRP levels, high rates of preoperative biliary stenting, lymph node metastases, and perineural invasion, and a lower rate of R0 resection than the high-GNRI group. Both OS and RFS in the low-GNRI group were significantly lower. In multivariate analysis, low GNRI was a significant predictor of poor OS (hazard ratio [HR], 1.731; 95% CI: 1.111–2.696; p = 0.015) and RFS (HR, 1.900; 95% CI: 1.231–2.931; p = 0.004), independently of inflammatory and tumour markers, as well as of pathological features.

Conclusions:
Preoperative GNRI may be an easily accessible predictor of poor prognosis in patients with BTC undergoing surgical resection.

keywords:

geriatric nutritional risk index, GNRI, biliary tract cancer, BTC, prognosis

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