Radiation exposure to the kidney with interstitial iridium-192 high-dose-rate brachytherapy: Extent and rare morphologic changes of radiation nephropathy

Christine March; Maximilian Thormann; Peter Hass; Max Seidensticker; Christian Gross; Jazan Omari; Maciej Pech; Robert Damm

doi:10.5114/jcb.2022.123970

eISSN: 2081-2841
ISSN: 1689-832X

Journal of Contemporary Brachytherapy

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abstract:

Original paper

Radiation exposure to the kidney with interstitial iridium-192 high-dose-rate brachytherapy: Extent and rare morphologic changes of radiation nephropathy

Christine March

¹

,

Maximilian Thormann

¹

,

Peter Hass

²

,

Max Seidensticker

³

,

Christian Gross

⁴

,

Jazan Omari

¹

,

Maciej Pech

¹

,

Robert Damm

^{1, 5}

Department of Radiology and Nuclear Medicine, Otto-von-Guericke-University Magdeburg, Germany
Department of Radiotherapy and Radiooncology, Helios-Klinikum Erfurt GmbH, Germany
Department of Radiology, Ludwig-Maximilians-University Munich, Germany
Department of Nephrology, Hypertensive Diseases, Diabetology and Endocrinology, Otto-von-Guericke-University Magdeburg, Germany
Radiology Practice, Dessau, Germany

J Contemp Brachytherapy 2022; 14, 6: 512–518

DOI: https://doi.org/10.5114/jcb.2022.123970

Online publish date: 2022/12/30

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AMA

March C, Thormann M, Hass P, et al. Radiation exposure to the kidney with interstitial iridium-192 high-dose-rate brachytherapy: Extent and rare morphologic changes of radiation nephropathy. Journal of Contemporary Brachytherapy. 2022;14(6):512-518. doi:10.5114/jcb.2022.123970.

APA

March, C., Thormann, M., Hass, P., Seidensticker, M., Gross, C.,  & Omari, J. et al. (2022). Radiation exposure to the kidney with interstitial iridium-192 high-dose-rate brachytherapy: Extent and rare morphologic changes of radiation nephropathy. Journal of Contemporary Brachytherapy, 14(6), 512-518. https://doi.org/10.5114/jcb.2022.123970

Chicago

March, Christine, Maximilian Thormann, Peter Hass, Max Seidensticker, Christian Gross, Jazan Omari,  and Maciej Pech et al. 2022. "Radiation exposure to the kidney with interstitial iridium-192 high-dose-rate brachytherapy: Extent and rare morphologic changes of radiation nephropathy". Journal of Contemporary Brachytherapy 14 (6): 512-518. doi:10.5114/jcb.2022.123970.

Harvard

March, C., Thormann, M., Hass, P., Seidensticker, M., Gross, C., Omari, J., Pech, M.,  and Damm, R. (2022). Radiation exposure to the kidney with interstitial iridium-192 high-dose-rate brachytherapy: Extent and rare morphologic changes of radiation nephropathy. Journal of Contemporary Brachytherapy, 14(6), pp.512-518. https://doi.org/10.5114/jcb.2022.123970

MLA

March, Christine et al. "Radiation exposure to the kidney with interstitial iridium-192 high-dose-rate brachytherapy: Extent and rare morphologic changes of radiation nephropathy." Journal of Contemporary Brachytherapy, vol. 14, no. 6, 2022, pp. 512-518. doi:10.5114/jcb.2022.123970.

Vancouver

March C, Thormann M, Hass P, Seidensticker M, Gross C, Omari J et al. Radiation exposure to the kidney with interstitial iridium-192 high-dose-rate brachytherapy: Extent and rare morphologic changes of radiation nephropathy. Journal of Contemporary Brachytherapy. 2022;14(6):512-518. doi:10.5114/jcb.2022.123970.

Purpose
We sought to investigate functional parameters and morphologic changes of the renal parenchyma after treatment with image-guided brachytherapy using single-fraction irradiation (high-dose-rate brachytherapy – HDR-BT) of primary kidney lesions, and primary and secondary lesions of the liver, lymph node, and adrenal gland close to renal structures.

Material and methods
Patients ineligible for surgery were included. We prospectively investigated renal function loss within one year via renal scintigraphy and laboratory parameters (KDOQI stage). Radiation exposure to the kidney was measured by volume receiving 5 Gy (V5). We observed morphologic changes on CT or MRI, with follow-up every three months.

Results
In total, 35 patients were included (21 males, 14 females). Eight patients were treated for extra-renal malignancies. The mean V5 of the ipsilateral kidney was 70.0 ±42.4 ml equaling to 44.9% parenchymal volume. After renal treatment, V5 renal volume was 77.8 ±42.2 ml (48.7%) compared with 44.0 ±33.0 ml (32.0%) after extra-renal treatment. No significant reduction in KDOQI stage after 12 months of follow-up were found. Three patients developed morphologic changes in the renal parenchyma, with only one showing a decrease in renal function after 12 months.

Conclusions
CT-guided HDR-BT is a viable treatment modality for local ablative treatment of renal and adjacent masses, with no significant reduction of the KDOQI stage as a predictor for complications of chronic kidney disease. However, larger cohorts need to be analyzed to identify vulnerable patients, as in rare cases, plain dosimetry seems insufficient to predict renal function loss after HDR-BT.

keywords:

Radiation exposure to the kidney with interstitial iridium-192 high-dose-rate brachytherapy: Extent and rare morphologic changes of radiation nephropathy

Christine March 1 , Maximilian Thormann 1 , Peter Hass 2 , Max Seidensticker 3 , Christian Gross 4 , Jazan Omari 1 , Maciej Pech 1 , Robert Damm 1, 5

brachytherapy, single-fraction irradiation, renal dysfunction, radiation-induced nephropathy

Christine March

¹

,

Maximilian Thormann

¹

,

Peter Hass

²

,

Max Seidensticker

³

,

Christian Gross

⁴

,

Jazan Omari

¹

,

Maciej Pech

¹

,

Robert Damm

^{1, 5}