eISSN: 2081-2841
ISSN: 1689-832X
Journal of Contemporary Brachytherapy
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3/2022
vol. 14
 
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abstract:
Case report

Radiation-induced undifferentiated spindle cell sarcoma following high-dose-rate interstitial brachytherapy for tongue squamous cell carcinoma

Yuka Uchimoto
1
,
Hiroaki Shimamoto
1, 2
,
Ami Takeshita
1
,
Kaori Oya
3
,
Mitsunobu Kishino
3
,
Yasuo Fukuda
3
,
Satoru Toyosawa
4
,
Michio Oda
5
,
Kazuhiko Ogawa
2
,
Sven Kreiborg
6, 7
,
Sanjay M. Mallya
8
,
Shumei Murakami
1, 2

  1. Department of Oral and Maxillofacial Radiology, Osaka University Graduate School of Dentistry, Osaka, Japan
  2. Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, Japan
  3. Clinical Laboratory, Osaka University Dental Hospital, Osaka, Japan
  4. Department of Oral Pathology, Osaka University Graduate School of Dentistry, Osaka, Japan
  5. Department of Medical Technology, Osaka University Hospital, Osaka, Japan
  6. Department of Pediatric Dentistry and Clinical Genetics, School of Dentistry, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
  7. 3D Craniofacial Image Research Laboratory (School of Dentistry, University of Copenhagen; Centre of Head and Orthopedics, Copenhagen University Hospital Rigshospitalet; and Department of Applied Mathematics and Computer Science, Technical University of Denmark), Copenhagen, Denmark
  8. Section of Oral and Maxillofacial Radiology, UCLA School of Dentistry, Los Angeles, USA
J Contemp Brachytherapy 2022; 14, 3: 268-272
DOI: https://doi.org/10.5114/jcb.2022.116149
Online publish date: 2022/05/11
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High-dose-rate interstitial brachytherapy (HDR-ISBT) has recently come to be considered one of the most effective treatments for oral cancer. On the other hand, it is important to note that radiation therapy has some side effects. Especially, radiation-induced malignancy is probably the most serious complication affecting long-term survivors. We report a case of a radiation-induced undifferentiated spindle cell sarcoma that developed following HDR-ISBT for tongue squamous cell carcinoma (SCC). A 39-year-old woman with right tongue SCC underwent HDR-ISBT (60 Gy, 10 fractions, 8 days) treatment. Five years and one month later, a tumor had developed at the primary site. Surgery was performed for the tumor, which was histopathologically diagnosed as an undifferentiated spindle cell sarcoma. That was distinct from the squamous cell origin of the primary cancer. According to recently established criteria for radiation-induced malignancy, this case was classified as a radiation-induced sarcoma. A search of the literature revealed no previous report of radiation-induced malignancy following HDR-ISBT for tongue cancer.
keywords:

radiation-induced, sarcoma, brachytherapy, tongue

  
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