Relationship between vitamin D in obstructive
sleep apnea syndrome and psoriasis patients

Hülya Albayrak; Nevin Fazlıoğlu; Bahadır Batar; Mehmet Emin Yanık; Mustafa Oran; Nejat Altıntaş

doi:10.5114/ada.2021.106031

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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Original paper

Relationship between vitamin D in obstructive sleep apnea syndrome and psoriasis patients

Hülya Albayrak

¹

,

Nevin Fazlıoğlu

²

,

Bahadır Batar

³

,

Mehmet Emin Yanık

⁴

,

Mustafa Oran

⁵

,

Nejat Altıntaş

²

Department of Dermatology, Namık Kemal University, Faculty of Medicine, Tekirdag, Turkey
Department of Chest Diseases, Namık Kemal University, Faculty of Medicine, Tekirdag, Turkey
Department of Medical Genetics, Namık Kemal University, Faculty of Medicine, Tekirdag, Turkey
Department of Dermatology, Sancaktepe Region Hospital, Istanbul, Turkey
Department of Internal Medicine, Namık Kemal University, Faculty of Medicine, Tekirdag, Turkey

Adv Dermatol Allergol 2022; XXXIX (2): 375-383

DOI: https://doi.org/10.5114/ada.2021.106031

Online publish date: 2021/10/25

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AMA

Albayrak H, Fazlıoğlu N, Batar B, Emin Yanık M, Oran M, Altıntaş N. Relationship between vitamin D in obstructive
sleep apnea syndrome and psoriasis patients. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2022;39(2):375-383. doi:10.5114/ada.2021.106031.

APA

Albayrak, H., Fazlıoğlu, N., Batar, B., Emin Yanık, M., Oran, M.,  & Altıntaş, N. (2022). Relationship between vitamin D in obstructive
sleep apnea syndrome and psoriasis patients. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 39(2), 375-383. https://doi.org/10.5114/ada.2021.106031

Chicago

Albayrak, Hülya, Nevin Fazlıoğlu, Bahadır Batar, Mehmet Emin Yanık, Mustafa Oran,  and Nejat Altıntaş. 2022. "Relationship between vitamin D in obstructive
sleep apnea syndrome and psoriasis patients". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 39 (2): 375-383. doi:10.5114/ada.2021.106031.

Harvard

Albayrak, H., Fazlıoğlu, N., Batar, B., Emin Yanık, M., Oran, M.,  and Altıntaş, N. (2022). Relationship between vitamin D in obstructive
sleep apnea syndrome and psoriasis patients. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 39(2), pp.375-383. https://doi.org/10.5114/ada.2021.106031

MLA

Albayrak, Hülya et al. "Relationship between vitamin D in obstructive
sleep apnea syndrome and psoriasis patients." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 39, no. 2, 2022, pp. 375-383. doi:10.5114/ada.2021.106031.

Vancouver

Albayrak H, Fazlıoğlu N, Batar B, Emin Yanık M, Oran M, Altıntaş N. Relationship between vitamin D in obstructive
sleep apnea syndrome and psoriasis patients. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2022;39(2):375-383. doi:10.5114/ada.2021.106031.

Introduction
Although psoriasis and obstructive sleep apnea syndrome (OSAS) are associated with systemic inflammation, studies on their potential bilateral relationship are not sufficient.
Aim: To investigate vitamin D levels and receptor gene polymorphisms in patients with OSAS and psoriasis and the associations with these diseases.

Material and methods
One hundred thirty-seven patients included in the study consisted of 4 different groups: group 1, those with both diseases; group 2, those with OSAS only; group 3, patients with psoriasis only; and group 4, healthy controls. The patients’ serum calcium, phosphorus, AHI, Epworth Sleepiness Scale, Psoriasis Area Severity Index, and VDR TagI, ApaI, BsmI polymorphisms were compared.

Results
Vitamin D levels of groups 1, 2 and 3 were found to be lower than in controls. There was no statistically significant correlation between VDR TagI, ApaI, BsmI gene polymorphisms of the groups. Vitamin D levels were significantly higher in patients with heterozygous ApaI genotype (A/C) compared to patients with normal (A/A) or homozygous mutant (C/C) genotype (p < 0.05). No relationship was determined between VDR TagI, ApaI, BsmI, and the other parameters.

Conclusions
In our study, 1,25(OH)2-vitamin D3 levels were significantly lower in all disease groups compared to the control group. Although there is no difference between the groups in terms of VDR gene polymorphism, we think that there may be a bidirectional relationship between these diseases based on the low vitamin D levels.

keywords:

Relationship between vitamin D in obstructive sleep apnea syndrome and psoriasis patients

Hülya Albayrak 1 , Nevin Fazlıoğlu 2 , Bahadır Batar 3 , Mehmet Emin Yanık 4 , Mustafa Oran 5 , Nejat Altıntaş 2

psoriasis, obstructive sleep apnea syndrome, vitamin D, VDR polymorphism

Hülya Albayrak

¹

,

Nevin Fazlıoğlu

²

,

Bahadır Batar

³

,

Mehmet Emin Yanık

⁴

,

Mustafa Oran

⁵

,

Nejat Altıntaş

²