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Anaesthesiology Intensive Therapy
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5/2023
vol. 55
 
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abstract:
Original article

Reporting SOFA in research: we should always present each of the SOFA subscores

Zbigniew Putowski
1
,
Marcelina Czok
1
,
Kamil Polok
2
,
Bertrand Guidet
3
,
Christian Jung
4
,
Raphael Romano Bruno
4
,
Dylan de Lange
5
,
Susannah Leaver
6
,
Rui Moreno
7, 8
,
Bernhard Wernly
9, 10
,
Hans Flaatten
11
,
Wojciech Szczeklik
1

  1. Centre for Intensive Care and Perioperative Medicine, Jagiellonian University Medical College, Kraków, Poland
  2. Department of Pulmonology, Jagiellonian University Medical College, Kraków, Poland
  3. Sorbonne Universités, UPMC Univ Paris 06, INSERM, UMR_S 1136, Institut Pierre Louis d’Epidémiologie et de Santé Publique, Equipe: Epidémiologie Hospitalière Qualité et Organisation des Soins, F-75012, Paris, France
  4. Department of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany
  5. Department of Intensive Care Medicine, University Medical Centre, University Utrecht, Utrecht, The Netherlands
  6. Department of Critical Care, St George’s Hospital, London, United Kingdom
  7. Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Faculdade de Ciências Médicas de Lisboa (Nova Médical School), Lisbon, Portugal
  8. Faculdade de Ciências da Saúde, Universidade da Beira Interior. Covilhã, Portugal
  9. Department of Internal Medicine, General Hospital Oberndorf, Teaching Hospital of the Paracelsus Medical University, Salzburg, Austria
  10. Institute of General Practice, Family Medicine and Preventive Medicine, Paracelsus Medical University of Salzburg, Salzburg, Austria
  11. Department of Anaesthesia and Intensive Care, Haukeland University Hospital, Bergen, Norway
Anaesthesiol Intensive Ther 2023; 55, 4: 326–329
DOI: https://doi.org/10.5114/ait.2023.134188
Online publish date: 2023/12/30
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Introduction:
The Sequential Organ Failure Assessment (SOFA) score is the sum of 6 components, each representing one organ system with dysfunction classified on a 4-point scale. In research, usually by default, the total SOFA score is taken into account, but it may not reflect the severity of the condition of the individual organs. Often, these values are expected to predict mortality.

Material and methods:
In this study, we reanalysed 2 cohorts of critically ill elderly patients to explore the distribution of SOFA subscores and to assess the between-group differences. Both cohorts were adjusted to maintain similarity in terms of age and the primary cause of admission (respiratory cause).

Results:
In total, 910 (non-COVID-19 cohort) and 551 patients (COVID-19 cohort) were included in the analysis. Both cohorts were similar in terms of the total SOFA score (median 5 vs. 5 points); however, the groups differed significantly in 4/6 SOFA subscores (respiratory, neurological, cardiovascular, and coagulation subscores). Moreover, the cohorts had different fractions of organ failures (defined as a SOFA subscore ≥ 3).

Conclusions:
This analysis revealed significant differences in SOFA subscores between the COVID-19 and non-COVID-19 respiratory cohorts, highlighting the importance of considering individual organ dysfunction rather than relying solely on the total SOFA score when reporting organ dysfunction in clinical research.

keywords:

Sequential Organ Failure Assessment, SOFA score, multiorgan dysfunction, organ failure
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