Resveratrol in the treatment of asthma based
on an animal model

Kamil Leis; Przemysław Gałązka; Jakub Kazik; Tomasz Jamrożek; Weronika Bereźnicka; Rafał Czajkowski

doi:10.5114/ada.2022.117543

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Review paper

Resveratrol in the treatment of asthma based on an animal model

Kamil Leis

¹

,

Przemysław Gałązka

¹

,

Jakub Kazik

¹

,

Tomasz Jamrożek

¹

,

Weronika Bereźnicka

¹

,

Rafał Czajkowski

²

Department of General and Oncologic Surgery for Children and Adolescents, Chair of Paediatrics, Haematology and Oncology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland
Chair of Dermatology and Venerology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland

Adv Dermatol Allergol 2022; XXXIX (3): 433-438

DOI: https://doi.org/10.5114/ada.2022.117543

Online publish date: 2022/07/15

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Resveratrol is a natural polyphenol found, for example, in red wine, grapes or nuts. One of the resveratrol’s health properties is a cardioprotective activity – it is believed that resveratrol is responsible for the French paradox and anticancer activity. Moreover, the effectiveness of resveratrol in the treatment of asthma is confirmed by multiple research. Resveratrol displays a multiway impact on the reduction of the symptoms of the disease which contributes to the alleviation of inflammation i.a. by: inhibition of cellular infiltration, suppression of oxidative stress, reduction in the volume of mucus, relaxation of smooth muscle, stalling of the fibrosis affecting the respiratory tract or counteracting bronchial hyperresponsiveness. Resveratrol reduces the concentration of eosinophils, pro-inflammatory interleukins and interferes with many signal transduction pathways. In case of concomitance of obesity, resveratrol alleviates the course of asthma. The review juxtaposes the mechanisms of resveratrol activity and presents the results of the published research conducted on rodents.

keywords:

Resveratrol in the treatment of asthma based on an animal model

Kamil Leis 1 , Przemysław Gałązka 1 , Jakub Kazik 1 , Tomasz Jamrożek 1 , Weronika Bereźnicka 1 , Rafał Czajkowski 2

resveratrol, natural polyphenol, asthma treatment

Kamil Leis

¹

,

Przemysław Gałązka

¹

,

Jakub Kazik

¹

,

Tomasz Jamrożek

¹

,

Weronika Bereźnicka

¹

,

Rafał Czajkowski

²