Review paper<br>Acquired facial lipoatrophy: pathogenesis and therapeutic options

Aneta Szczerkowska-Dobosz; Barbara Olszewska; Małgorzata Lemańska; Dorota Purzycka-Bohdan; Roman Nowicki

doi:10.5114/pdia.2014.40971

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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Review paper
Acquired facial lipoatrophy: pathogenesis and therapeutic options

Aneta Szczerkowska-Dobosz

,

Barbara Olszewska

,

Małgorzata Lemańska

,

Dorota Purzycka-Bohdan

,

Roman Nowicki

Postep Derm Alergol 2015; XXXII, 2:127 –133

DOI: https://doi.org/10.5114/pdia.2014.40971

Online publish date: 2015/03/30

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Facial lipoatrophy refers to the loss of subcutaneous fat tissue presenting by flattening or indentation of convex contour of the face. Facial lipoatrophy is a feature of the normal ageing process. It may be also a manifestation of chronic diseases, most frequently it affects HIV-infected individuals treated with highly active antiretroviral therapy (HAART) and may constitute a complication of connective tissue diseases, like lupus erythematosus profundus or morphea. Early recognition and treatment of the active stage of connective tissue diseases is of essential significance in prevention of subsequent scarring and atrophy lesions. In HIV-positive patients undergoing HAART therapy, the attempt to modify thetreatment scheme so it has a less lipemic effect seems to be justified. Esthetic correction of facial lipoatrophy in chronic diseases is a great challenge. Improvement of appearance is very important for affected individuals, because it diminishes their stigmatization and psychosocial dysfunction. Facial volumetric correction includes surgical and dermatological procedures such as adipose transfer and injectable dermal fillers.

keywords:

Review paperAcquired facial lipoatrophy: pathogenesis and therapeutic options

Aneta Szczerkowska-Dobosz , Barbara Olszewska , Małgorzata Lemańska , Dorota Purzycka-Bohdan , Roman Nowicki

face lipoatrophy, connective tissue diseases, highly active antiretroviral therapy

Review paper
Acquired facial lipoatrophy: pathogenesis and therapeutic options

Aneta Szczerkowska-Dobosz

,

Barbara Olszewska

,

Małgorzata Lemańska

,

Dorota Purzycka-Bohdan

,

Roman Nowicki