Review paper<br>Vitamin D and its receptor – role and activity in the human body. Anomalies of metabolism and structure associated with psoriasis

Magdalena Kolanko; Ligia Brzezińska-Wcisło

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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3/2011
vol. 28

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abstract:

Review paper
Vitamin D and its receptor – role and activity in the human body. Anomalies of metabolism and structure associated with psoriasis

Magdalena Kolanko

,

Ligia Brzezińska-Wcisło

Post Dermatol Alergol 2011; XXVIII, 3: 212–216

Online publish date: 2011/07/01

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Psoriasis is a common, chronic and recurrent inflammatory dermatosis with abnormally exaggerated epidermal cellular turnover, which affects about 2.5% of the world’s population. One of the therapeutic modalities for the treatment of moderate skin lesions is phototherapy with NB-UVB radiation (311 nm). The 290-315 nm UV radiation produces in the epidermis vitamin D of 7-dehydrocholesterol which is then hydroxylated into 25(OH)D and 1,25(OH)2D. Active metabolites of vitamin D, apart from regulating calcium-phosphorus homeostasis, have been shown to inhibit hyperproliferation and to induce terminal differentiation of cultured human keratinocytes through their action on the genome by the nuclear receptor VDR (vitamin D receptor). The literature includes many studies on VDR gene polymorphism and abnormal vitamin D metabolism in some patients with psoriasis. These anomalies could be possibly connected to adverse reactions to NB-UVB and treatment with vitamin D analogues.

keywords:

Review paperVitamin D and its receptor – role and activity in the human body. Anomalies of metabolism and structure associated with psoriasis

Magdalena Kolanko , Ligia Brzezińska-Wcisło

psoriasis, vitamin D metabolism, VDR polymorphism

Review paper
Vitamin D and its receptor – role and activity in the human body. Anomalies of metabolism and structure associated with psoriasis

Magdalena Kolanko

,

Ligia Brzezińska-Wcisło