Review paper<br>
Interleukin 18 – a pleiotropic cytokine involved in the Th1 and Th2 immunological response

Magdalena Trzeciak; Małgorzata Sokołowska-Wojdyło; Wioletta Barańska-Rybak; Agata Maciejewska; Igor Michajłowski; Jadwiga Roszkiewicz

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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4/2011
vol. 28

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abstract:

Review paper
Interleukin 18 – a pleiotropic cytokine involved in the Th1 and Th2 immunological response

Magdalena Trzeciak

,

Małgorzata Sokołowska-Wojdyło

,

Wioletta Barańska-Rybak

,

Agata Maciejewska

,

Igor Michajłowski

,

Jadwiga Roszkiewicz

Post Dermatol Alergol 2011; XXVIII, 4: 309–312

Online publish date: 2011/08/31

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AMA

Trzeciak M, Sokołowska-Wojdyło M, Barańska-Rybak W, Maciejewska A, Michajłowski I, Roszkiewicz J. Review paper
Interleukin 18 – a pleiotropic cytokine involved in the Th1 and Th2 immunological response. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2011;28(4):309-312.

APA

Trzeciak, M., Sokołowska-Wojdyło, M., Barańska-Rybak, W., Maciejewska, A., Michajłowski, I.,  & Roszkiewicz, J. (2011). Review paper
Interleukin 18 – a pleiotropic cytokine involved in the Th1 and Th2 immunological response. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 28(4), 309-312.

Chicago

Trzeciak, Magdalena, Małgorzata Sokołowska-Wojdyło, Wioletta Barańska-Rybak, Agata Maciejewska, Igor Michajłowski,  and Jadwiga Roszkiewicz. 2011. "Review paper
Interleukin 18 – a pleiotropic cytokine involved in the Th1 and Th2 immunological response". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 28 (4): 309-312.

Harvard

Trzeciak, M., Sokołowska-Wojdyło, M., Barańska-Rybak, W., Maciejewska, A., Michajłowski, I.,  and Roszkiewicz, J. (2011). Review paper
Interleukin 18 – a pleiotropic cytokine involved in the Th1 and Th2 immunological response. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 28(4), pp.309-312.

MLA

Trzeciak, Magdalena et al. "Review paper
Interleukin 18 – a pleiotropic cytokine involved in the Th1 and Th2 immunological response." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 28, no. 4, 2011, pp. 309-312.

Vancouver

Trzeciak M, Sokołowska-Wojdyło M, Barańska-Rybak W, Maciejewska A, Michajłowski I, Roszkiewicz J. Review paper
Interleukin 18 – a pleiotropic cytokine involved in the Th1 and Th2 immunological response. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2011;28(4):309-312.

Interleukin 18 (IL-18) is a pleiotropic cytokine that plays a crucial role in the control of the balance between the Th1 and Th2 response. Synergistically with IL-12, IL-18 promotes an immunological response of the TH1 type, by enhancing INF-γ synthesis and inhibition of IgE production. On the other hand, IL-18 can enhance IL-4 and IL-13 production and stimulates IgE synthesis. Moreover, in the presence of IL-3, IL-18 can directly stimulate basophils and mast cells to produce their mediators. The gene of IL-18 is located on chromosome 11q22.2-22.3, which was identified as an important candidate region for susceptibility to atopy. The aim of this paper is to characterize IL-18, the evolution of views on it and to emphasize the influence of IL-18 on the development of infectious, inflammatory, autoimmune diseases and malignancies with a special consideration of atopic diseases.

keywords:

Review paper Interleukin 18 – a pleiotropic cytokine involved in the Th1 and Th2 immunological response

Magdalena Trzeciak , Małgorzata Sokołowska-Wojdyło , Wioletta Barańska-Rybak , Agata Maciejewska , Igor Michajłowski , Jadwiga Roszkiewicz

interleukin 18, immunoglobulin E, lymphocytes Th1 and Th2

Review paper
Interleukin 18 – a pleiotropic cytokine involved in the Th1 and Th2 immunological response

Magdalena Trzeciak

,

Małgorzata Sokołowska-Wojdyło

,

Wioletta Barańska-Rybak

,

Agata Maciejewska

,

Igor Michajłowski

,

Jadwiga Roszkiewicz