SAPHO syndrome: pathogenesis, clinical presentation,
imaging, comorbidities and treatment: a review

Hanna Przepiera-Będzak; Marek Brzosko

doi:10.5114/ada.2020.97394

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

6/2021
vol. 38

Send email

Copy url:

abstract:

Review paper

SAPHO syndrome: pathogenesis, clinical presentation, imaging, comorbidities and treatment: a review

Hanna Przepiera-Będzak

¹

,

Marek Brzosko

¹

Department of Rheumatology, Internal Medicine, Geriatrics and Clinical Immunology, Pomeranian Medical University, Szczecin, Poland

Adv Dermatol Allergol 2021; XXXVIII (6): 937–942

DOI: https://doi.org/10.5114/ada.2020.97394

Online publish date: 2020/07/23

View full text Get citation

Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome is a constellation of dermatological and osteoarticular symptoms. The pathogenesis of SAPHO is unknown, but infectious, genetic, immunological and environmental factors may play a role. SAPHO is classified along two different spectrums: pustulo-psoriatic hyperostotic spondyloarthritis and chronic recurrent multifocal osteomyelitis. The typical skin lesions are palmoplantar pustulosis and acne. The sign of arthritis is involvement of the anterior chest wall, most often the sternoclavicular joints. There are no standard treatment recommendations, but nonsteroidal anti-inflammatory drugs, sulfasalazine, methotrexate, antibiotics and biological drugs can be considered.

keywords:

SAPHO syndrome: pathogenesis, clinical presentation, imaging, comorbidities and treatment: a review

Hanna Przepiera-Będzak 1 , Marek Brzosko 1

synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO), pathogenesis, clinical presentation, imaging, comorbidities, treatment

Hanna Przepiera-Będzak

¹

,

Marek Brzosko

¹